Philip Jon Rosenthal

Whole-genome characterization of Plasmodium falciparum population structure and drug resistance across Uganda and neighboring countries

The paper characterizes the population structure and drug resistance of Plasmodium falciparum in Uganda and neighboring countries using whole-genome data, identifying key resistance-associated haplotypes.

PfPHAST: Plasmodium falciparum Public Health Amplicon Sequencing Tool, a Streamlined Panel for Malaria Genomic Surveillance

PfPHAST is a streamlined amplicon sequencing panel for malaria genomic surveillance, offering better quality control and cost efficiency than MAD4HatTeR without sacrificing performance on shared targets.

Bradykinin Contributes to Vasogenic Edema in Murine Experimental Cerebral Malaria

This study shows that bradykinin contributes to vasogenic edema in murine cerebral malaria, and its inhibition improves outcomes when combined with artesunate.

Identifying a next-generation antimalarial trioxolane in a landscape of artemisinin partial resistance

The paper describes the discovery of new antimalarial trioxolanes effective against artemisinin-resistant parasites and their potential as development candidates for malaria treatment.

A novel locus associated with decreased susceptibility of Plasmodium falciparum to lumefantrine and dihydroartemisinin has emerged and spread in Uganda

Placental Malaria Induces a Unique Methylation Profile Associated with Fetal Growth Restriction

The paper compares methylation profiles of placentas with non-malarial and PM-associated FGR, finding distinct differentially methylated CpGs and a shared hypomethylated site in BMP4.

The Impact of Antimalarial Resistance on the Genetic Structure of Plasmodium falciparum in the DRC

This study analyzes the genetic structure of Plasmodium falciparum in the DRC, identifying an east-west haplotype divide linked to antimalarial resistance and evidence of gene flow and selection pressures.