Author

Matthew P. Tracey

University of PennsylvaniaORCID 0000-0002-8015-9016Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Organism:Drosophila· 1 Research Focus:gene regulatory network inference· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Kristen W. LynchiD· 2 shared Aayushi P. Shah· 1 shared Beatriz M. A. FontouraiD· 1 shared Bertram L. JacobsiD· 1 shared Bridget E. BeggiD· 1 shared Christopher J. FieldsiD· 1 shared Deirdre C. Tatomer· 1 shared Dongming LiangiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

Kristen W. LynchORCID

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3 papers

Recent·Most cited

Nonsense-mediated decay controls a negative feedback loop in innate immune sensing

Simon Boudreault, Yahira Rivera-Lopez, Max Ferretti, Matthew P. Tracey, James Bonner, Bertram L. Jacobs, Kristen W. Lynch

The paper shows that dsRNA sensing inhibits NMD, forming a negative feedback loop that limits dsRNA-mediated immune responses.

Proceedings of the National Academy of Sciences · Jan 9, 2026Peer-reviewedImmunology

Coordination of nuclear RNA processing by speckle-localized kinase TAOK2

Bridget E. Begg, Matthew P. Tracey, Shengyan Gao, Svetlana Ernest, Mohd Altaf Najar, George M. Burslem, Melanie H. Cobb, Beatriz M. A. Fontoura, Kristen W. Lynch

This study identifies TAOK2 as a kinase that regulates splicing and export of both viral and cellular transcripts by phosphorylating SRRM1/2, maintaining nuclear speckle structure and function.

bioRxiv · Sep 29, 2025Molecular Biology

IntS6 and the Integrator phosphatase module tune the efficiency of select premature transcription termination events

Rina Fujiwara, Si-Nan Zhai, Dongming Liang, Aayushi P. Shah, Matthew P. Tracey, Xu-Kai Ma, Christopher J. Fields, Maria Saraí Mendoza-Figueroa, Michele C. Meline, Deirdre C. Tatomer, Li Yang, Jeremy E. Wilusz

The paper shows that IntS6 recruits PP2A to regulate transcription termination efficiency at specific genes, highlighting the phosphatase module's selective role in Integrator complex function.

Molecular Cell · Nov 22, 2023Peer-reviewedMolecular Biology