Author

Jila Ajeian

University College London

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Developmental Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:bulk RNA-seq· 2 Organism:chicken / avian· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Claire Mary SmithiD· 3 shared Maximillian N. J. WoodalliD· 3 shared Daniel H. GoldhilliD· 2 shared Ian Hay BrowniD· 2 shared Jessica L. QuantrilliD· 2 shared Jiayun YangiD· 2 shared Katie‐Marie CaseiD· 2 shared Munir IqbaliD· 2 shared

Activity by Year

2022-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

Claire Mary SmithORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Bovine H5N1 influenza viruses have adapted to more efficiently use receptors abundant in cattle

Jack A. Hassard, Jiayun Yang, Dorothy E. D. P. Hawkins, Jonathan E. Pekar, Bernadeta Dadonaite, Jin Yu, Samuel Richardson, Rute Maria Pinto, Kristel Ramirez Valdez, Philippe Lemey, Jessica L. Quantrill, Chris Neil, Lorin Adams, Jinghan Xue, Natacha S. Ogando, , Thomas P. Peacock

This study shows bovine H5N1 influenza viruses have adapted to efficiently use NeuGc receptors in cattle, enhancing replication without significantly altering zoonotic risk.

bioRxiv · Oct 10, 2026 · PreprintMicrobiology

Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals.

Vidhi Dholakia, Jessica L. Quantrill, Samuel A. S. Richardson, Nunticha Pankaew, Maryn D. Brown, Jiayun Yang, Fernando Capelastegui, Tereza Masonou, Katie‐Marie Case, Jila Ajeian, Maximillian N. J. Woodall, Callum Magill, Graham Freimanis, Amy Mccarron, Ecco Staller, , Daniel H. Goldhill

Cattle B3.13 H5N1 polymerase gained PB2 M631L and PA K497R, boosting replication in bovine and human cells via better bovine ANP32A use; later PB2 E627K and D740N add activity.

Nature Communications · Jan 16, 2026Peer-reviewedMicrobiology✦ In-depth digest

Antiviral drug synergy and mutational signatures in different epithelial cell models of RSV and hPIV infection

Samuel Ellis, Amy I. Jacobs, Shengyuan Zhang, Laura Buggiotti, Maximillian N. J. Woodall, Jila Ajeian, Helena J. Tutill, Charles M. Miller, Macheala Palor, Angelika Kopec, Elizabeth K. Haughey, Hongxia Ma, Mia Tomlinson, Rachel J. Williams, Christopher O’Callaghan, , Judith Breuer

This study evaluates antiviral drug synergy and mutational signatures of RdRp inhibitors against RSV and hPIV in epithelial cell models and primary airway cultures.

bioRxiv · Jan 13, 2026 · PreprintMicrobiology

PAX4 loss of function alters human endocrine cell development and influences diabetes risk

Hwee Hui Lau, Nicole A. J. Krentz, Fernando Abaitua, Marta Perez‐Alcantara, Jun Wei Chan, Jila Ajeian, Soumita Ghosh, Benoite Champon, Han Sun, Alokkumar Jha, Shawn S. Hoon, Nguan Soon Tan, Daphne Su-Lyn Gardner, Shih Ling Kao, E Shyong Tai, , Adrian Kee Keong Teo

This study shows that PAX4 variants reduce beta cell function and increase diabetes risk by impairing insulin secretion and hormone gene expression in human cells.

bioRxiv · May 15, 2022 · PreprintDevelopmental Biology