Xavier Montagutelli

Polygenic viral factors enable efficient mosquito-borne transmission of African Zika virus

The paper identifies polygenic viral factors in African Zika virus strains that enhance mosquito transmission efficiency compared to Asian strains.

Identification of a unique TUBB3+ cell population in the tuberculosis granuloma

The paper identifies a TUBB3+ cell population in TB granulomas across multiple species and patients, distinct from known cell types and present in other infections.

Intranasal delivery of a broadly neutralizing single domain antibody targeting ACE2 protects against SARS-CoV-2 infection

This paper develops a single domain antibody targeting ACE2 that protects against SARS-CoV-2 infection in mice when delivered intranasally.

stuart: an R package for the curation of SNP genotypes from experimental crosses

stuart curates SNP genotypes from experimental crosses by filtering markers based on informativeness, Mendelian inheritance, and parental consistency.

Genetic diversity of Collaborative Cross mice controls viral replication, clinical severity and brain pathology induced by Zika virus infection, independently of Oas1b

This study shows that genetic diversity in Collaborative Cross mice affects ZIKV infection outcomes, including viral replication and disease severity, independent of Oas1b.

Genetic dissection of Rift Valley fever pathogenesis: Rfvs2 on mouse chromosome 11 enables survival to acute-onset hepatitis

This study identifies Rvfs2 as a genetic locus that restricts RVFV replication and enables survival from acute liver disease in mice.