José Ángel Nicolás-Ávila

Broad therapeutic benefit of myosin inhibition in hypertrophic cardiomyopathy

This study shows that myosin inhibition with mavacamten is effective in treating HCM caused by both truncating and missense variants in MYBPC3, despite different pathomechanisms.

HDL-associated phosphatidylserine blunts myeloid activation and protects from atherosclerosis

This study identifies phosphatidylserine as an anti-inflammatory biomarker and shows that HDL-associated PS reduces atherosclerosis through plaque stabilization and immune modulation in mice.

Vascular HIF2 signaling prevents cardiomegaly, alveolar congestion and capillary remodeling during chronic hypoxia

This study shows that HIF2 signaling in the Wt1 lineage prevents cardiomegaly and pulmonary remodeling during chronic hypoxia but causes microvascular instability and cardiac dysfunction when absent.