Richard A. Hickman

Neuropathological evidence of reduced amyloid beta and neurofibrillary tangles in multiple sclerosis cortex

This study finds reduced amyloid beta and neurofibrillary tangles in MS cortex compared to controls, with age-dependent patterns and a correlation between Aβ and NFT density.

Multi-OMIC analysis of Huntington disease reveals a neuroprotective astrocyte state

This study uses multi-omic analysis to identify a neuroprotective astrocyte state in Huntington disease that correlates with delayed disease onset and neuroprotection.

A cross-disease human microglial framework identifies disease-enriched subsets and tool compounds for microglial polarization.

This study identifies disease-enriched microglial subsets and validates compounds that modulate their states using single-cell RNA sequencing and in vitro experiments.