Author

Ali Cenk Aksu

Koç UniversityORCID 0000-0002-6525-3602Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:drug response / drug discovery· 4 Approach:experimental assay· 4 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Approach:genetic perturbation / CRISPR· 2 Approach:statistical model· 2 Research Focus:clustering· 1

Frequent Co-Authors

Adam P. CribbsiD· 4 shared Tugba Bagci OnderiD· 4 shared Ozlem Yedier-BayramiD· 3 shared Ahmet CingöziD· 2 shared Altar OzbıyıkiD· 2 shared Ayşe Hümeyra Dur KarasayariD· 2 shared Ebru YilmaziD· 2 shared Filiz Senbabaoglu AksuiD· 2 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersCancer Biology

Adam P. CribbsORCID

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Author profile →

5 papers

Recent·Most cited

DDRKOL: A Focused CRISPR Library for Systematic Identification of DNA Damage Response Dependencies in Glioblastoma

Canan Bayraktar, İpek Kok, Altar Ozbıyık, Alişan Kayabölen, Ali Cenk Aksu, Ayşe Hümeyra Dur Karasayar, İlknur Sur‐Erdem, İbrahim Kulaç, Tugba Bagci Onder

DDRKOL identifies essential DDR genes in glioblastoma using CRISPR screens, revealing four high-confidence candidates validated across multiple assays and models.

bioRxiv · Sep 13, 2026 · PreprintCancer Biology

Targeting CBP/p300 Overcomes Acquired Vincristine Resistance in Medulloblastoma

Göktuğ Karabiyik, Ozlem Yedier-Bayram, Feridun Aksu, Tolga Lokumcu, Ali Cenk Aksu, Fidan Seker-Polat, Ezgi Ozyerli‐Goknar, Adam P. Cribbs, Udo C. T. Oppermann, Tugba Bagci Onder

This study identifies CBP/p300 inhibition as a strategy to overcome vincristine resistance in medulloblastoma by targeting genes involved in drug resistance.

bioRxiv · Jul 28, 2026 · PreprintCancer Biology

Fibroblast specialisation across microanatomy in a single-cell atlas of healthy human Achilles tendon

C. Cohen, Jolet Y. Mimpen, Alina Kurjan, Claudia Paul, Shreeya Sharma, Lorenzo Ramos‐Mucci, Chinemerem T Ikwanusi, Ali Cenk Aksu, Tracy Boakye Serebour, Marina Nikolic, Kévin Rue-Albrecht, Christopher Gibbons, Duncan Whitwell, Thomas D. A. Cosker, Stephen E. Gwilym, , Sarah J. B. Snelling

The paper creates a single-cell atlas of the healthy human Achilles tendon, identifying six fibroblast subtypes with distinct spatial distributions and transcriptional profiles.

bioRxiv · Oct 17, 2025 · PreprintGenomics

Functional Genomic Screens Reveal RBBP4 as a Key Regulator of Cell Cycle Progression in TMZ-Resistant Glioblastoma

Ezgi Yağmur Kala, Filiz Senbabaoglu Aksu, Muhammed Erdem Ercan, Altar Ozbıyık, Ahmet Cingöz, Ozlem Yedier-Bayram, Ali Cenk Aksu, Ayşe Derya Cavga, Ebru Yilmaz, İpek Kok, Ayşe Hümeyra Dur Karasayar, İbrahim Kulaç, Hamzah Syed, Martin Philpott, Adam P. Cribbs, Tugba Bagci Onder

This study identifies RBBP4 as a critical regulator of cell cycle progression in TMZ-resistant glioblastoma through CRISPR screens and functional analyses.

bioRxiv · May 9, 2025 · PreprintCancer Biology

Chromatin-focused genetic and chemical screens identify BRPF1 as a targetable vulnerability in Taxol-resistant triple-negative breast cancer

Ozlem Yedier-Bayram, Ahmet Cingöz, Ebru Yilmaz, Ali Cenk Aksu, Beril Esin, N. Pinarbasi Degirmenci, Ayse Derya Cavga, Beyza Dedeoğlu, Buse Cevatemre, Hamzah Syed, Martin Philpott, Adam P. Cribbs, Udo Oppermann, Nathan A. Lack, Ceyda Acilan, , Tugba Bagci-Onder

The paper identifies BRPF1 as a key regulator of Taxol resistance in TNBC through genetic and chemical screens, showing its inhibition sensitizes resistant cells to chemotherapy.

bioRxiv · Apr 16, 2024Cancer Biology