Guilin Wang

Oncostatin M-driven leak in human endothelial cells with preserved tight junctions

This study identifies oncostatin M-driven vascular leak in human endothelial cells through nanoscale channel formation, distinct from junction disassembly, and highlights potential therapeutic targets.

Multicellular Spatial Programs Define the Histopathological Architecture of Meningioma

This study identifies multicellular spatial molecular programs in meningiomas using multi-omic data and develops a model to infer these programs from histopathology.

Transcriptional Determinism and Stochasticity Contribute to the Complexity of Autism Associated SHANK Family Genes

The paper profiles the SHANK3 transcriptome using cDNA-capture and long-read sequencing, revealing complex transcript variants altered in Shank3 mutants and ASD brains, improving variant detection in neuropsychiatric disorders.

Reduced progranulin increases tau and alpha-synuclein inclusions and alters phenotypes of tauopathy mice via glucocerebrosidase

This study shows that reduced progranulin increases tau and alpha-synuclein inclusions and worsens tauopathy mouse phenotypes via glucocerebrosidase.

Single-cell longitudinal analysis of SARS-CoV-2 infection in human airway epithelium

Time-course single-cell RNA sequencing of infected human bronchial epithelial cultures reports ciliated cells as a major target, with tropism later widening to basal and club cells.