Author

Shumpei Niida

Medical Genome Center, National Center for Geriatrics and GerontologyORCID 0000-0002-6192-8035Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 4 Genetics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 6 Approach:statistical model· 6 Research Focus:GWAS / association mapping· 3 Assay:GWAS summary statistics· 3 Research Focus:differential expression· 2 Approach:Bayesian inference· 1 Assay:bulk RNA-seq· 1 Assay:DNA methylation· 1

Frequent Co-Authors

Kouichi OzakiiD· 6 shared Shigeo MurayamaiD· 3 shared Akinori MiyashitaiD· 2 shared Akiyoshi KakitaiD· 2 shared Chikashi C. TeraoiD· 2 shared Kensaku KasugaiD· 2 shared Masataka KikuchiiD· 2 shared Norikazu HaraiD· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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6 shared papersGenetic & Genomic Medicine

Kouichi OzakiORCID

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6 papers

Recent·Most cited

Association of rare APOE missense variants with Alzheimer's disease in the Japanese population

Akinori Miyashita, Ai Obinata, Norikazu Hara, Risa Mitsumori, Daita Kaneda, Yoshio Hashizume, Terunori Sano, Masaki Takao, Ramil Gabdulkhaev, Mari Tada, Akiyoshi Kakita, Akira Arakawa, Maho Morishima, Shigeo Murayama, Yuko Saito, , Takeshi Ikeuchi

The paper identifies APOE rare missense variants in the Japanese population and finds two variants associated with protective effects against Alzheimer's disease.

medRxiv · Nov 5, 2024 · PreprintGenetic & Genomic Medicine

Polygenic effects on the risk of Alzheimer's disease in the Japanese population

Masataka Kikuchi, Akinori Miyashita, Norikazu Hara, Kensaku Kasuga, Yuko Saito, Shigeo Murayama, Akiyoshi Kakita, Hiroyasu Akatsu, Kouichi Ozaki, Shumpei Niida, Ryozo Kuwano, Takeshi Iwatsubo, Akihiro Nakaya, Takeshi Ikeuchi, the Alzheimer’s Disease Neuroimaging Initiative, , Gary R. Conrad

This paper evaluates the polygenic risk score for Alzheimer's disease in Japanese individuals, showing its utility despite genetic differences from European populations.

Alzheimer s Research & Therapy · Feb 27, 2024Peer-reviewedGenetic & Genomic Medicine

Exploring the genetic diversity of the Japanese Population: Insights from a Large-Scale Whole Genome Sequencing Analysis

Yosuke Kawai, Yusuke Watanabe, Yosuke Omae, Reiko Miyahara, Seik‐Soon Khor, Eisei Noiri, Koji Kitajima, Hideyuki Shimanuki, Hiroyuki Gatanaga, Kenichiro Hata, Kotaro Hattori, Aritoshi Iida, Hatsue Ishibashi-Ueda, Tadashi Kaname, Tatsuya Kanto, , Katsushi Tokunaga

This study uses whole-genome sequencing of 9,850 Japanese samples to analyze genetic diversity, revealing population declines and natural selection linked to agriculture and food production.

PLoS Genetics · Dec 7, 2023Peer-reviewedGenomics

Genetic insights into ossification of the posterior longitudinal ligament of the spine

Yoshinao Koike, Masahiko Takahata, Masahiro Nakajima, Nao Otomo, Hiroyuki Suetsugu, Xiaoxi Liu, Tsutomu Endo, Shiro Imagama, Kazuyoshi Kobayashi, Takashi Kaito, Satoshi Kato, Yoshiharu Kawaguchi, Masahiro Kanayama, Hiroaki Sakai, Takashi Tsuji, , Shiro Ikegawa

This study identifies genetic loci and causal traits associated with ossification of the posterior longitudinal ligament of the spine using GWAS and Mendelian randomization analyses.

eLife · Jun 16, 2023Peer-reviewedGenetic & Genomic Medicine

Lower DNA methylation levels in CpG island shores of CR1, CLU, and PICALM genes in the blood of Alzheimer's disease patients

Risa Mitsumori, Kazuya Sakaguchi, Daichi Shigemizu, Taiki Mori, Shintaro Akiyama, Kouichi Ozaki, Shumpei Niida, Nobuyoshi Shimoda

The paper examines DNA methylation levels in AD-related genes in blood and finds lower methylation in CR1, CLU, and PICALM in AD patients, with potential diagnostic value.

PLoS ONE · Sep 29, 2020Peer-reviewedGenetic & Genomic Medicine

Large scale genome-wide association study in a Japanese population identified 45 novel susceptibility loci for 22 diseases

Kazuyoshi Ishigaki, Masato Akiyama, Masahiro Kanai, Atsushi Takahashi, Eiryo Kawakami, Hiroki Sugishita, Saori Sakaue, Nana Matoba, Siew‐Kee Low, Yukinori Okada, Chikashi C. Terao, Tiffany Amariuta, Steven Gazal, Yuta Kochi, Momoko Horikoshi, , Yoichiro Kamatani

A large-scale GWAS in 212,453 Japanese individuals identified 45 novel susceptibility loci for 22 diseases, highlighting the importance of non-European population studies.

Nature Genetics · Jun 8, 2020Peer-reviewedGenetics