Author

Edwin G. Tse

University of North Carolina at Chapel HillORCID 0000-0002-9133-9274Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1

Frequent Co-Authors

Anirban GhoshaliD· 2 shared Daniel N. StreblowiD· 2 shared John D. SearsiD· 2 shared Mark T. HeiseiD· 2 shared Mohammad Anwar HossainiD· 2 shared Nathaniel J. MoormaniD· 2 shared Rafael M. CouñagoiD· 2 shared Timothy Mark WillsoniD· 2 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersPharmacology & Toxicology

Anirban GhoshalORCID

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2 papers

Recent·Most cited

N-Alkyl Sulfamates as a New Class of nsP2 Cysteine Protease Inhibitors with Broad Spectrum Antialphaviral Activity

Anirban Ghoshal, John D. Sears, Mohammad Anwar Hossain, Edwin G. Tse, Stefanie Howell, Jane Burdick, Noah L. Morales, Sabian A. Martinez, Isabella Law, Zachary J. Streblow, Daniel N. Streblow, Rafael M. Couñago, Nathaniel J. Moorman, Mark T. Heise, Timothy Mark Willson

Journal of Medicinal Chemistry · Oct 15, 2025Peer-reviewedPharmacology & Toxicology

Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach

Eric M. Merten, John D. Sears, Tina M. Leisner, P. Brian Hardy, Anirban Ghoshal, Mohammad Anwar Hossain, Kesatebrhan Haile Asressu, Peter J. Brown, Edwin G. Tse, Michael A. Stashko, Kelin Li, Jacqueline L. Norris-Drouin, Laura E. Herring, Angie L. Mordant, Thomas S. Webb, , Kenneth H. Pearce

This paper identifies and characterizes RA-0002034, a covalent inhibitor of CHIKV nsP2 protease, showing potent inhibition and selectivity against alphaviruses.

Proceedings of the National Academy of Sciences · Oct 10, 2024Peer-reviewedBiochemistry