Author

Kazuo Tsubota

Keio UniversityORCID 0000-0002-8874-7111Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:benchmarking· 1 Assay:DNA methylation· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Hideyuki OkanoiD· 2 shared Kenta KobayashiiD· 2 shared Motoshi HayanoiD· 2 shared Naho SerizawaiD· 2 shared Toshihide KuriharaiD· 2 shared Yusaku KatadaiD· 2 shared A.V. RukminiiD· 1 shared Abhirup DasiD· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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2 shared papersNeuroscience

Hideyuki OkanoORCID

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5 papers

Recent·Most cited

ENLIGHT Consensus Checklist and Guidelines for reporting laboratory studies on the non-visual effects of light in humans

Manuel Spitschan, Laura Kervezee, Renske Lok, Elise M. McGlashan, Raymond P. Najjar, Annette E. Allen, Marilyne Andersen, Salvador Bará, Peter Blattner, Christine Blume, Diane B. Boivin, María‐Ángeles Bonmatí‐Carrión, Kai Broszio, Timothy M. Brown, Sarah L. Chellappa, , Jamie Marc Zeitzer

The paper develops a consensus checklist and guidelines for reporting non-visual light effects in human studies, resulting in a 25-item checklist after expert feedback.

EBioMedicine · Dec 1, 2023Peer-reviewedNeuroscience

Starburst amacrine cells amplify optogenetic visual restoration through gap junctions in the murine retina

Yusaku Katada, Hiromitsu Kunimi, Naho Serizawa, Deokho Lee, Kenta Kobayashi, Kazuno Negishi, Hideyuki Okano, Kenji F. Tanaka, Kazuo Tsubota, Toshihide Kurihara

The paper demonstrates that optogenetic actuators in starburst amacrine cells enhance visual restoration in murine retinas through gap junctions.

Molecular Therapy — Methods & Clinical Development · May 11, 2023Peer-reviewedNeuroscience

Violet light modulates the central nervous system to regulate memory and mood

Nobunari Sasaki, Pooja Gusain, Motoshi Hayano, Tetsuro Kawano-Sugaya, Naoya Tonegawa, Yusuke Hatanaka, Risako Tamura, Kei Okuyama, Hideto Osada, Norimitsu Ban, Yasue Mitsukura, Richard A. Lang, Masaru Mimura, Kazuo Tsubota

This study shows that violet light improves memory and mood in aged mice by activating OPN5-positive retinal ganglion cells and modulating brain regions like the habenula.

bioRxiv · Nov 2, 2021 · PreprintNeuroscience

High-sensitivity vision restoration via ectopic expression of chimeric rhodopsin in mice

Yusaku Katada, Kazuho Yoshida, Naho Serizawa, Kenta Kobayashi, Kazuno Neghisi, Hideyuki Okano, Hideki Kandori, Kazuo Tsubota, Toshihide Kurihara

The paper demonstrates that ectopic expression of chimeric rhodopsin in mice restores dim-light vision and prevents retinal degeneration.

bioRxiv · Sep 17, 2020 · PreprintNeuroscience

DNA Break-Induced Epigenetic Drift as a Cause of Mammalian Aging

Motoshi Hayano, Jae-Hyun Yang, Michael S. Bonkowski, João A. Amorim, Jaime M. Ross, Giuseppe Coppotelli, Patrick T. Griffin, Yap Ching Chew, Wei Guo, Xiaojing Yang, Daniel L. Vera, Elias Salfati, Abhirup Das, Sachin Thakur, Alice E. Kane, , David A. Sinclair

The paper shows that DNA double-strand breaks induce epigenomic changes that accelerate the aging clock in mammals.

bioRxiv · Oct 21, 2019 · PreprintMolecular Biology