Mathias Langner

Droplet single-cell CRISPR screens identify regulators of T cell-mediated target-cell killing

The paper uses droplet single-cell CRISPR screening to identify regulators of T cell-mediated target-cell killing and finds that mTORC1 modulation enhances cytotoxic activity.

Human heart organoids reveal a regenerative strategy for mitochondrial disease

The paper uses human heart organoids to model mitochondrial disease and identifies a drug that improves mitochondrial function and tissue contractility.

AZIN2-dependent polyamine metabolism determines adipocyte progenitor fate and protects against obesity and dysmetabolism

This study identifies AZIN2 as a regulator of adipocyte progenitor fate through polyamine metabolism, showing its protective role against obesity and metabolic dysfunction.