Author

Azzam Ismail

Leeds Teaching Hospitals NHS TrustORCID 0000-0002-9019-6881Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Assay:imaging· 1 Research Focus:spatial domain detection· 1 Approach:statistical model· 1

Frequent Co-Authors

Lucy F. SteadiD· 2 shared Adelheid WöehreriD· 1 shared Allison K Lowman· 1 shared Ana C. deCarvalhoiD· 1 shared Ana Valeria CastroiD· 1 shared Andrea Transou· 1 shared Andrew J. FilbyiD· 1 shared Andrew R Brodbelt· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

Lucy F. SteadORCID

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2 papers

Recent·Most cited

Spatial profiling of longitudinal glioblastoma reveals consistent changes in cellular architecture, post-treatment

Shoaib Ajaib, Joshua Winter-Luke, Richard John Digby, Steven Pollock, Gemma Hemmings, Arief Gusnanto, Aruna Chakrabarty, Azzam Ismail, Erica Wilson, Bethany Hunter, Andrew J. Filby, David McDonald, Asa A. Brockman, Rebecca A. Ihrie, Lucy F. Stead

This study uses imaging mass cytometry to analyze changes in glioblastoma tumor microenvironment before and after treatment, finding increased normal brain cells and altered cellular interactions post-treatment.

Neuro-Oncology · Aug 6, 2025Peer-reviewedCancer Biology

The epigenetic evolution of gliomas is determined by their IDH1 mutation status and treatment regimen

Tathiane Maistro Malta, Thaís S. Sabedot, Natalia S. Morosini, Indrani Datta, Luciano Garofano, Wies Vallentgoed, Frederick S. Varn, Kenneth Aldape, Fulvio D’Angelo, Spyridon Bakas, Jill S. Barnholtz‐Sloan, Hui Kong Gan, Mohammad Hasanain, Ann‐Christin Hau, Kevin C. Johnson, , Peter S. LaViolette

This study analyzes the epigenetic evolution of IDH1-mutant and IDH1-wildtype gliomas under treatment, showing IDHmut tumors undergo epigenomic changes resembling IDHwt tumors, with implications for treatment strategies.

Cancer Research · Dec 20, 2023Peer-reviewedGenomics