Scott D. Pletcher

Neuronal FICD shapes motivated behavior through modulation of dopamine receptor dynamics

This study shows that FICD modulates dopamine receptor dynamics in neurons, affecting motivated behavior in Drosophila, C. elegans, and mice.

Learning fly pose from vision-language annotations

This paper uses a vision-language model to generate annotations for fruit fly pose estimation, achieving high accuracy and enabling efficient training of pose estimation networks.

Regeneration leads to global tissue rejuvenation in aging sexual planarians

Regeneration in aging planarians reverses age-related physiological and molecular changes, restoring youthful gene expression and tissue composition.

me31B regulates stem cell homeostasis by preventing excess dedifferentiation in the Drosophila male germline.

This study shows that me31B prevents excessive dedifferentiation of spermatogonia into germline stem cells in Drosophila, maintaining stem cell homeostasis by regulating nos.

Serotonin signaling modulates aging-associated metabolic network integrity in response to nutrient choice

This study shows that dietary choice affects metabolic network integrity in aging Drosophila through serotonin signaling, altering network structure and organism resilience.

Serotonin and dopamine modulate aging in response to food perception and availability

The paper identifies compounds that block food perception in C. elegans, increasing longevity by modulating serotonin and dopamine signaling, suggesting a mechanism by which dietary restriction mimetics extend lifespan.

Serotonin 2A receptor signaling coordinates central metabolic processes to modulate aging in response to nutrient choice

This study shows that nutrient choice affects aging in Drosophila through serotonin 2A receptor signaling and metabolic reprogramming.

Perception of naturally dead conspecifics impairs health and longevity through serotonin signaling in Drosophila

This study shows that Drosophila perceives dead conspecifics, which affects health and longevity through serotonin signaling.