Author

Patrick Matthys

KU LeuvenORCID 0000-0002-9685-6836Unclaimed ORCID profile · follow to get notified of new preprints

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Patrick Matthys2 papers

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Assay:flow cytometry· 1

Frequent Co-Authors

Abhimanyu Kumar SinghiD· 1 shared Adrian ListoniD· 1 shared Annelies StevaertiD· 1 shared Arnout R. D. VoetiD· 1 shared Benjamin Van LoyiD· 1 shared Bert VanmecheleniD· 1 shared Besir KrasniqiiD· 1 shared Brent De WijngaertiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMicrobiology

Abhimanyu Kumar SinghORCID

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2 papers

Recent·Most cited

Adult patients with autoinflammation of unknown origin partially phenocopy the immune presentation of Still's disease

Rafael Veiga, Leana De Vuyst, Christophe Poulet, Julika Neumann, Leoni Bücken, Teresa Prezzemolo, Mathijs Willemsen, S. Vanderschueren, Patrick Matthys, Emna Chabaane, Maximilien Fléron, Gaël Cobraiville, Dominique Baiwir, Gabriel Mazzucchelli, Bruno Fautrel, , Adrian Liston

The paper compares immunological profiles of patients with autoinflammation of unknown origin to healthy controls and Still's disease patients, identifying shared biomarkers and immune features.

Nature Communications · Apr 1, 2026Peer-reviewedImmunology

A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses

Benjamin Van Loy, Eugènia Pujol, Kenichi Kamata, Xiao Yin Lee, Nikolai Bakirtzoglou, Ria Van Berwaer, Julie Vandeput, Cato Mestdagh, Leentje Persoons, Brent De Wijngaert, Quinten Goovaerts, Sam Noppen, Maarten Jacquemyn, Kourosh Ahmadzadeh, Eline Bernaerts, , Annelies Stevaert

This paper identifies EPB-113, a guanidine-based inhibitor of coronavirus nsp15 endoribonuclease, which suppresses viral replication and selects for interferon-susceptible mutants.

PLoS Pathogens · Feb 11, 2025Peer-reviewedMicrobiology