Naofumi Uesaka

Automatic quantification of disgust reactions in mice using machine learning

This paper develops a machine learning method to automatically quantify disgust reactions in mice, achieving high correlation with manual counts.

Innate liking and disgust reactions elicited by intraoral capsaicin in male mice

This study shows that capsaicin induces liking and disgust reactions in male mice through orofacial and bodily responses, similar to taste reactivity.

Whole-Brain Three-Dimensional Imaging of RNAs at Single-Cell Resolution

The paper develops TRIC-DISCO, a pipeline for whole-brain 3D RNA imaging in adult mice, enabling single-cell resolution of transcriptional signatures and markers without strict RNase-free conditions.

Viral vectors with cluster of differentiation gene promoters to target specific cell types in the brain

The paper develops AAV vectors with CD promoters to target specific brain cell types, demonstrating their utility in studying interneuron function and treating autism-like behaviors.

Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity

This study shows that oligodendrocytes regulate synchronized neural activity during development, affecting adult behavior through Purkinje cell synchrony.

AUTS2 Governs Cerebellar Development, Purkinje Cell Maturation, Motor Function and Social Communication

This study investigates the role of AUTS2 in cerebellar development, Purkinje cell maturation, and behavioral functions, finding that its loss leads to cerebellar defects and behavioral impairments linked to ASDs.