Author

Hugues Lortat‐Jacob

Centre National de la Recherche ScientifiqueORCID 0000-0002-9772-0762Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Neuroscience· 2 Immunology· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:Drosophila· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Ana BoulangeriD· 2 shared Jean‐Maurice DuraiD· 2 shared Rabia SadiriD· 2 shared Alexandre StellaiD· 1 shared Anja K. Münster-KühneliD· 1 shared Anne Gonzalez de PeredoiD· 1 shared Aurélien BoyanceiD· 1 shared Camille GorltiD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersNeuroscience

Ana BoulangerORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Glycosaminoglycan presentation-dependent regulation of glial responses by Orion during Drosophila neuronal pruning

Charline Gal, Clarisse Perron, Sylvain D. Vallet, Evelyne Gout, Margot Weber, Oulidi Fatima Ezzahra, Hui Ji, Chun Han, Hugues Lortat‐Jacob, Jean‐Maurice Dura, Ana Boulanger

This study shows that Orion's presentation via glycosaminoglycans regulates distinct glial responses during Drosophila neuronal pruning.

bioRxiv · Oct 5, 2026 · PreprintNeuroscience

ST8SIA4-mediated polysialylation is critical for CCR2-driven monocyte egress from the bone marrow

Aurélien Boyance, Nelly Gilles, Maxime Rotival, Alexandre Stella, Camille Gorlt, Karima Chaoui, Sarah Monard, Nacho Aguiló, Thomas Mangeat, Odile Burlet‐Schiltz, Hugues Lortat‐Jacob, Anja K. Münster-Kühnel, Anne Gonzalez de Peredo, Denis Hudrisier, Lluís Quintana‐Murci, , Yoann Rombouts

This study identifies ST8SIA4-mediated polysialylation as essential for CCR2-driven monocyte egress from the bone marrow, revealing a novel regulatory mechanism in immune cell trafficking.

bioRxiv · Jan 12, 2026 · PreprintImmunology

Structure of the human heparan sulfate polymerase complex EXT1-EXT2

Francisco Leisico, Juneina Omeiri, Christine Le Narvor, Joël Beaudouin, Michael Hons, Daphna Fenel, Guy Schoehn, Yohann Couté, David Bonnaffé, Rabia Sadir, Hugues Lortat‐Jacob, Rebekka Wild

The paper presents the cryo-EM structure of the human EXT1-EXT2 complex, revealing its dimeric architecture and catalytic specificity in heparan sulfate biosynthesis.

Nature Communications · Nov 19, 2022Peer-reviewedMolecular Biology

Axon-secreted chemokine-like Orion is a signal for astrocyte infiltration during neuronal remodeling

Ana Boulanger, Camille Thinat, Stephan L. Zuchner, Lee G. Fradkin, Hugues Lortat‐Jacob, Jean‐Maurice Dura

The paper identifies a new gene, orion, which is secreted by neurons and recruits astrocytes for axon pruning and debris removal during neuronal remodeling in Drosophila.

bioRxiv · Nov 23, 2020 · PreprintNeuroscience