M. Joanne Lemieux

This paper identifies an activation hotspot on SERCA using cryo-EM structures of SERCA bound to two activators, revealing structural insights for rational drug design.

This paper identifies TMX2 as a regulator of ER-mitochondria contacts by preventing TOM70 sulfenylation, linking its dysfunction to neurodevelopmental disorders.

This study shows GlpG protease is essential for type 1 pili assembly in E. coli, affecting biofilm formation and bacterial fitness.

This paper develops a genetically encoded fluorescent biosensor for extracellular L-lactate and demonstrates its use in imaging in cultured mammalian cells and brain tissue.

This paper develops improved photocleavable proteins with faster and more efficient dissociation for better optogenetic control.