Petr Kouba

Uncovering Functional Distant Mutations by Ultra-High-Throughput Screening of Dehalogenases

This study uses ultrahigh-throughput screening to identify mutations in dehalogenases that modulate substrate access and binding, revealing distal functional effects on enzyme dynamics.

Taurine Inhibits Apolipoprotein E4 Aggregation

This study shows taurine inhibits ApoE4 aggregation and reduces its pathophysiological effects, similar to tramiprosate and 3-sulfopropanoic acid.

Isolation of structural constraints by ensemble-conditioned protein sequence design

This paper introduces Caliby, a sequence design method that conditions on structural ensembles to improve designability while reducing native sequence recovery.

Conditional Protein Structure Generation with Protpardelle-1c

Protpardelle-1c is a protein structure generative model that improves motif scaffolding and multi-chain complex generation, achieving higher scores and faster sampling than existing models.