Simon M. G. Braun

This study identifies GCNT2 as a glycosylation-dependent checkpoint that restrains intestinal intra-epithelial lymphocyte (IEL) activation by modifying CD45 and dampening TCR signaling.

This study identifies niche-specific chromatin and metabolic states in adult mouse neural stem cells that influence their neuronal fate potential.

The paper shows that SMARCD paralogs exhibit functional redundancy but also specialized roles in neurodevelopment, with SMARCD3 uniquely regulating oxidative phosphorylation.

The paper identifies CNIH1 as a key factor for GPCR export using a CRISPR screen and cargo-release assay, showing its role in transporting DOR to the plasma membrane.

The paper identifies Mlf2 and Rbm15 as regulators of SWI/SNF complex activity through CRISPR screening in mouse embryonic stem cells, revealing their roles in chromatin remodeling and m6A RNA methylation.

The paper identifies SOX2 as a super pioneer factor that inhibits DNA methylation maintenance at its binding sites through passive demethylation during replication.

This study shows that the BAF complex both antagonizes and promotes polycomb-mediated repression by redistributing polycomb complexes across the genome in embryonic stem cells.

The paper shows that switching from npBAF to nBAF chromatin complexes controls cell cycle exit and promotes neural differentiation in developing mouse brains.