John J. Mekalanos

This paper presents two new antibody-recruiting molecule (ARM) strategies to combat multidrug-resistant bacterial infections using synthetic peptides and dimeric antibiotics.

This study shows that acetylation of CRP K52 activates AR3, leading to changes in gene expression that affect sugar utilization and virulence in V. cholerae.

This study identifies 13 genes essential for extreme colistin resistance in Pseudomonas aeruginosa using transposon insertion sequencing and validates novel pathways contributing to resistance.

This study determines the structure of Vibrio phage Peru-2, revealing its multimodal adsorption strategy and infection mechanism involving tailspikes and interactions with bacterial surfaces.

This study shows that the Aeromonas dhakensis strain A603 prevents AHPND in shrimp by removing pathogenic Vibrio and restoring microbiota balance through T6SS and phenazine.

The paper identifies Attractin as the receptor for Nigritoxin, a Vibrio toxin, and shows that related toxins use this receptor but have distinct effector domains.

The paper identifies residue covariance networks in SARS-CoV-related viruses to reveal evolutionary interactions important for their emergence as human pathogens.