James Morgan Gardner

The paper develops and validates an ultra-low-cost, open-source normothermic ex vivo organ perfusion platform for perfusing porcine kidneys and human organs.

This study shows Fezf2 regulates mTEC lineage commitment and homeostasis, with transcriptional repression playing a key role in maintaining thymic epithelial populations.

The paper benchmarks large language models for cell-type and gene set annotation using AnnDictionary, finding high accuracy in cell-type annotation and strong functional gene set recovery.

This study compares human and mouse ovarian biology across age using 3D-imaging, single-cell transcriptomics, and functional studies, identifying species-specific and age-related changes in follicle dynamics and gene expression.

This study identifies OPG-secreting CAFs as immunosuppressive stromal cells and shows that blocking OPG promotes immune infiltration and tumor regression in mouse models.

This study shows that a short-term high-fat diet during the onset of psoriasis worsens disease severity through immune system changes, even after returning to a normal diet.

The paper identifies five discrete metabolic domains in the mouse and human small intestine using transcriptional signatures and machine learning, showing how diet influences domain properties.

This paper describes a genome editing strategy that restores hemoglobin production in α-thalassemia major-derived hematopoietic stem and progenitor cells by integrating a functional α-globin gene and a truncated erythropoietin receptor.

Nearly 500,000 cells from 24 human tissues, many from one donor, characterize over 400 cell types and enable within-donor study of T-cell clones, B-cell mutation rates and splicing.