David J. Luginbuhl

Endosome-associated Rab GTPases control distinct aspects of neural circuit assembly

This study identifies the distinct roles of Rab5 and Rab11 in regulating neural circuit assembly through endosome-mediated trafficking.

Heterophilic interactions between cell-surface proteins Teneurin-m and Capricious drive dendrite segregation in the Drosophila olfactory circuit

Endocytome profiling uncovers cell-surface protein dynamics underlying neuronal connectivity

The paper introduces endocytome profiling to map cell-surface protein dynamics in developing olfactory receptor neurons, revealing how endocytosis regulates axon pruning and targeting.

Directed evolution of the multicopper oxidase laccase for cell surface proximity labeling and electron microscopy

This study evolves a laccase enzyme for cell surface labeling and EM, showing it can map T cell surface changes and visualize cell features without toxic H2O2.

Dimensionality reduction simplifies synaptic partner matching in an olfactory circuit

The paper shows that dimensionality reduction simplifies synaptic partner matching in the fly antennal lobe by reducing a 3D search problem to a 1D trajectory.

Repulsive interactions instruct synaptic partner matching in an olfactory circuit

The paper identifies three CSP pairs mediating repulsive interactions that prevent non-cognate synaptic connections in Drosophila olfactory circuits.

Molecular and Cellular Mechanisms of Teneurin Signaling in Synaptic Partner Matching

This study identifies the intracellular signaling pathway of teneurins in synaptic partner matching using Drosophila models.

Origin of wiring specificity in an olfactory map: dendrite targeting of projection neurons

This study investigates how projection neurons in Drosophila establish wiring specificity in the olfactory map through lineage, birth order, and dynamic dendrite remodeling during development.

Transcription Factor Acj6 Controls Dendrite Targeting via CombinatorialCell-Surface Codes

This study identifies Acj6 as a transcription factor that controls dendrite targeting in Drosophila PNs by regulating combinatorial expression of cell-surface proteins.

Temporal evolution of single-cell transcriptomes of Drosophila olfactory projection neurons

The paper analyzes single-cell transcriptomes of Drosophila olfactory projection neurons across developmental stages to identify transcriptomic changes and cellular diversity patterns.

Cellular Bases of Olfactory Circuit Assembly Revealed by Systematic Time-lapse Imaging

The paper uses time-lapse imaging in Drosophila to study how olfactory receptor neurons target axons to specific glomeruli, revealing dynamics of branching and bilateral interactions.

GluD2- and Cbln1-mediated Competitive Synaptogenesis Shapes the Dendritic Arbors of Cerebellar Purkinje Cells

This study shows that GluD2 and Cbln1 mediate competitive synaptogenesis, shaping Purkinje cell dendritic arbors in the cerebellum through competitive synapse formation.

Cell-Surface Proteomic Profiling in the Fly Brain Uncovers New Wiring Regulators

The paper profiles cell-surface proteomes in Drosophila olfactory neurons across development, identifying new regulators of neural circuit assembly.

Trans-synaptic Fish-lips Signaling Prevents Misconnections between Non-synaptic Partner Olfactory Neurons

This paper identifies Fish-lips (Fili) as a transmembrane protein that mediates repulsion between non-synaptic partner neurons to ensure precise wiring in the Drosophila olfactory circuit.

Functional divergence of Plexin B structural motifs in distinct steps of Drosophila olfactory circuit assembly

The paper investigates the functional roles of different structural motifs in Drosophila Plexin B during olfactory circuit assembly, revealing their distinct contributions to neurodevelopmental processes.

Coordinating Receptor Expression and Wiring Specificity in Olfactory Receptor Neurons

The paper identifies transcription factors that coordinate olfactory receptor expression and wiring specificity in Drosophila ORNs using single-cell RNA-sequencing and genetic analysis.

Classifying Drosophila Olfactory Projection Neuron Subtypes by Single-cell RNA Sequencing

This study uses single-cell RNA sequencing to classify Drosophila olfactory projection neuron subtypes and identifies key transcription factors and molecular codes involved in their specification.

Fibroblast Growth Factor Signaling Instructs Ensheathing Glia Wrapping of Drosophila Olfactory Glomeruli

The paper shows that fibroblast growth factor signaling guides ensheathing glia to wrap Drosophila olfactory glomeruli, ensuring proper compartment formation and axon targeting.

Presynaptic LRP4 Promotes Synapse Number and Function of Excitatory CNS Neurons

This study shows that presynaptic LRP4 promotes synapse number and function in excitatory CNS neurons in Drosophila by acting through SRPK79D.