Georg Vogler

Deficiency in MICOS component Chchd3 Compromises Drosophila Heart Function via mitophagy, ROS and ER Stress

This study shows that Chchd3 deficiency in Drosophila hearts impairs function through mitophagy, ROS, and ER stress, with partial rescue by antioxidant and ER stress interventions.

Cell type specific allometry controls sex-differences in Drosophila body size

The paper identifies sex-specific allometric strategies in Drosophila organs, showing how cell size and number differ between sexes to drive body size differences.

Functional analysis across model systems implicates ribosomal proteins in growth and proliferation defects associated with hypoplastic left heart syndrome

The paper identifies ribosomal protein genes as contributors to hypoplastic left heart syndrome through functional analysis across multiple model systems.

PI(4,5)P2 role in Transverse-tubule membrane formation and muscle function

This study identifies the PI(4,5)P2 pathway's role in T-tubule formation and muscle function using Drosophila models.

Mitochondrial MICOS complex genes, implicated in hypoplastic left heart syndrome, maintain cardiac contractility and actomyosin integrity

The paper identifies mitochondrial MICOS complex genes, CHCHD3 and CHCHD6, as contributors to hypoplastic left heart syndrome through functional studies in Drosophila and genetic analysis of patient cohorts.

A single DPE core promoter motif contributes to in vivo transcriptional regulation and affects cardiac function

The paper shows that a single DPE core promoter motif mutation in Drosophila affects cardiac function by disrupting Tinman's regulatory network.

Genetic architecture of natural variation of cardiac performance in flies: from flies to Humans

The paper identifies genetic networks and regulatory elements associated with cardiac performance variation in Drosophila and finds conserved genetic architecture between flies and humans.

Nascent Polypeptide Associated Complex-alpha and Signal Recognition Particle are required for cardiac development and remodeling

This study identifies NAC and SRP as novel regulators of cardiac development and remodeling in Drosophila and human cardiac progenitors, showing their spatial and temporal regulation in heart formation.

Conserved Role of the Large Conductance Calcium-Activated Potassium Channel, KCa1.1, in Sinus Node Function and Arrhythmia Risk

The paper investigates the role of KCa1.1 in sinus node function and arrhythmia risk across species, finding conserved effects of its loss of function.

A complete single-cell atlas of the embryonic Drosophila heart and the cell-type specific role of Tinman

The paper creates a single-cell atlas of the Drosophila embryonic heart and identifies Tinman's cell-type-specific roles in cardiac development.

Identification of MYOM2 as a candidate gene in hypertrophic cardiomyopathy and Tetralogy of Fallot and its functional evaluation in the Drosophila heart

The paper identifies MYOM2 as a candidate gene for hypertrophic cardiomyopathy and Tetralogy of Fallot and shows its functional role in heart development through Drosophila models.

Patient-specific functional genomics and disease modeling suggest a role for LRP2 in Hypoplastic Left Heart Syndrome

The paper identifies LRP2 as a novel genetic driver of hypoplastic left heart syndrome using whole genome sequencing and multi-model systems.