This paper introduces cTACs, synthetic molecules that degrade PD-L1 across immune and tumor cells, enhancing T cell activation and tumor suppression in vivo.

bioRxiv · Oct 2, 2026 · PreprintImmunology

High-fidelity enhanced AsCas12a knock-in mice for efficient multiplexed gene editing, disease modeling and orthogonal immunogenetics

Kaiyuan Tang, Xiaoyu Zhou, Shao‐Yu Fang, Erica Vandenbulcke, Andrew Du, Johanna Shen, Hanbing Cao, Jerry Zhou, Krista Chen, Xin Shan, Liqun Zhou, Shawn H. Lin, Medha Majety, Xingyu Ling, Stanley Z. Lam, , Sidi Chen

bioRxiv · Mar 14, 2024 · PreprintBioengineering

Cas12a/Cpf1 knock-in mice enable efficient multiplexed immune cell engineering

Matthew B. Dong, Kaiyuan Tang, Xiaoyu Zhou, Johanna Shen, Krista Chen, Hyunu R. Kim, Jerry Zhou, Hanbing Cao, Erica Vandenbulcke, Yueqi Zhang, Ryan Dz-Wei Chow, Andrew Du, Kazushi Suzuki, Shao‐Yu Fang, Medha Majety, , Sidi Chen

The paper demonstrates efficient multiplexed gene editing in immune cells using Cas12a/Cpf1 knock-in mice and associated viral vectors.

bioRxiv · Mar 14, 2023 · PreprintGenetics

The aging transcriptome and cellular landscape of the human lung in relation to SARS-CoV-2

Ryan Dz-Wei Chow, Medha Majety, Sidi Chen

This study examines age-related changes in the human lung transcriptome and cellular composition, linking them to increased COVID-19 severity in older adults.

Nature Communications · Jan 4, 2021Peer-reviewedGenomics