Author

Victoria Tripple

Salk Institute for Biological StudiesORCID 0009-0002-0191-4165Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

Susan M. KaechiD· 2 shared Alev BaysoyiD· 1 shared Alexandra C. NewtoniD· 1 shared Anna-Maria GlobigiD· 1 shared Bryan McDonaldiD· 1 shared Gabriela A. PizzurroiD· 1 shared H. Kay ChungiD· 1 shared Hannah M. Knox· 1 shared

Activity by Year

2024-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersSystems Biology

Susan M. KaechORCID

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2 papers

Recent·Most cited

Mapping intratumoral myeloid-T cell interactomes at single-cell resolution reveals targets for overcoming checkpoint inhibitor resistance

Kate Bridges, Gabriela A. Pizzurro, Alev Baysoy, Janani P. Baskaran, Ziyan Zoe Xu, Varsha Mathew, Victoria Tripple, Michael LaPorte, Koonam Park, William Damsky, Harriet M. Kluger, Rong Fan, Susan M. Kaech, Marcus Bosenberg, Kathryn Miller‐Jensen

The paper develops a computational method to analyze single-cell RNA-seq data to study cell-cell interactions in tumors, showing that CD40 agonist enhances immune checkpoint blockade by modulating myeloid-T cell interactions.

bioRxiv · Oct 28, 2024 · PreprintSystems Biology

Different signaling interpretations by PKC eta and theta control T cell function and exhaustion

Thomas H. Mann, Hannah M. Knox, Shixin Ma, Jesse Furgiuele, Anna-Maria Globig, Michael A. LaPorta, H. Kay Chung, Bryan McDonald, Majid Ghassemian, Steven Zhao, Hubert Tseng, Yagmur Farsakoglu, Victoria Tripple, Johnny Koo, Alexandra C. Newton, Susan M. Kaech

This study shows PKC theta sustains T cell function while PKC eta drives terminal exhaustion, with distinct downstream cascades and therapeutic implications for cancer immunotherapy.

bioRxiv · Sep 26, 2024 · PreprintImmunology