Nicolas Busquet

NF-kB/NLRP3 Translational Inhibition by Nanoligomer Therapy Mitigates Ethanol and Advanced Age-Related Neuroinflammation

This study shows that binge ethanol increases NLRP3+ microglia in aged mice, and that Nanoligomer therapy reduces ethanol-induced neuroinflammation and tau hyperphosphorylation.

CaV3.1 T-type calcium channels regulate spatial memory processing in the dorsal subiculum

This study shows that CaV3.1 T-type calcium channels in the dorsal subiculum regulate burst firing, synaptic plasticity, and spatial memory in mice.

Interferon receptor gene dosage determines multiple hallmarks of Down syndrome

The paper shows that correcting interferon receptor gene dosage in a mouse model of trisomy 21 rescues multiple key phenotypes associated with Down syndrome.