comparative / phylogenetic analysis

This paper shows Tris inhibits GH1 β-glucosidase via linear mixed inhibition, reducing enzyme-substrate affinity and affecting kinetic parameters.

This study uses micro-CT and CFD to analyze hemodynamic changes in murine AVF over time, identifying geometric and flow alterations linked to stenosis risk.

This study investigates how NF45-NF90 heterodimers bind and coat long dsRNA, revealing structural changes and implications for RNA processing.

This paper identifies enzymes in the oleuropein biosynthesis pathway in olive using comparative transcriptomics and discovers novel genes involved in the pathway.

This study identifies deoxyphomenone biosynthesis gene clusters in Hansfordia pulvinata and related Aspergillus species, showing horizontal gene transfer and adaptive evolution in mycoparasitism.

This study identifies uncharacterized NSPs and variations in molecular toolkits across mammalian and non-mammalian arteriviruses using comparative genomics and sequence-structure analysis.

This study compares droplet-based single-cell sequencing platforms to help researchers select the most suitable one for their applications.

The paper identifies three yeast lineages with reduced DNA repair genes and high evolutionary rates, showing how gene loss can lead to persistent hypermutator phenotypes.

This study reconstructs hormone-bHLH regulatory networks in Solanaceae, showing evolutionary changes in bHLH genes and regulatory rewiring under PSTVd infection in tomato.

This study shows how polyploidy in Brachypodium hybridum enhances drought adaptation through genomic legacies and subgenome expression biases.

This study identifies lipocalins in mosses as regulators of development and stress response, revealing their conserved function across land plants.

This study identifies EcpK as a bacterial tyrosine pseudokinase essential for exopolysaccharide biosynthesis in Myxococcus xanthus, showing it functions as a scaffold rather than through phosphorylation.

The paper identifies 16 independent origins of ectomycorrhizal symbiosis in rosid lineages and finds convergent gene duplications in cell wall remodeling genes.

The paper identifies and analyzes circadian clock and light-input pathway genes in Hemiptera, revealing lineage-specific gene losses and splicing variants, as well as a horizontal gene transfer event.

This study characterizes the structure and dynamics of GAD65 and its interaction with autoantibody b96.11, revealing how intrinsic conformational flexibility drives autoantigenicity.

The paper identifies novel Microviridae phages from horse uteri and suggests similar viruses may exist in related animals' uterine microbiomes.

This study identifies convergent genomic expansions in gene families related to blood-feeding in mosquitoes and sandflies using phylogenomics.

This study uses computational modeling to show that methadone blocks multiple ionic currents, leading to synergistic arrhythmias including long QT and Brugada-like patterns.

The paper investigates how dosage compensation in Drosophila is regulated during development by analyzing 3D genome structures and histone modifications across sexes and tissues.

This study compares a 2022 MPXV lineage B.1 virus with its clade IIb ancestor A.1, showing attenuated phenotypes including reduced virulence and immune evasion.

The paper studies Rickettsiales microbiomes in placozoans to reveal evolutionary shifts towards mutualism, finding some symbionts have lost parasitic traits.

The paper examines sex chromosomes in 14 elasmobranch species, identifying conserved X chromosomes and a shared candidate gene for sex determination.

The paper presents a macrogenetic atlas of prokaryotes integrating genomic and population genetic data to analyze evolutionary dynamics and selection-driven structures.

This study compares phage defense systems in Pseudomonas aeruginosa strains from cystic fibrosis and non-cystic fibrosis patients, finding fewer defenses in CF strains.

The paper analyzes NLR evolution in lettuce and related species, finding that sensor NLRs evolve faster than helper NLRs and that sensor diversification is linked to helper dependency.

This study reveals the structural mechanisms of IL-36R activation by IL-36γ and IL-37 and spesolimab's allosteric antagonism, providing a blueprint for therapeutic targeting.

This study identifies remotely located residues and conformational dynamics as regulators of kinetic properties in homologous glutamate dehydrogenases.

The paper identifies a sub-functionalized biosynthetic gene cluster in Physalis grisea, showing epigenetic regulation and tissue-specific expression of withanolide biosynthesis.

The paper identifies a novel ancestral high redox potential quinone, methyl-plastoquinone, and shows its evolutionary origin predates the Great Oxygenation Event.

This study identifies evolutionary changes in Rad51 and Dmc1 that influence recombination outcomes by altering DNA binding properties and pathway stability.