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The paper develops a Herbivore-Carnivore index to assess diet and health in human gut microbiota, finding humans fall between herbivores and carnivores with diet and health linked to HC-index values.

The paper identifies telotrons, telomeric repeat-containing introns, in multiple eukaryotic genomes and suggests telomerase drives intron creation and remodeling.

This paper uniformly re-analyzes public omics data from exercise studies in humans and rodents, providing standardized effect sizes and meta-analyses across multiple tissues and molecular layers.

This study shows that dual inhibition of MLK3 and LRRK2 with URMC-099 reduces PD pathology and motor deficits in an AAV-haSyn rat model.

This study links ER stress and impaired NAD biosynthesis via QPRT to reduced oocyte quality and shows that NMN supplementation improves oocyte function and early embryonic development.

This paper expands the RatGTEx resource with transcriptome-wide associations across 3,160 RNA-seq samples, identifying 7,473 gene-trait links and 144,876 QTLs for 22,599 genes.

This study evaluates AAV9-mediated SLC9A6 gene replacement in shaker rats, showing early treatment preserves cerebellar structure and motor function, while later treatment has diminishing effects.

This study examines how sex, exercise, and ovariectomy affect offensive and defensive aggression in rats, finding sex-specific behavioral differences and no effect of exercise.

This study develops an extended Pavlovian conditioned approach paradigm in Long-Evans rats under time-restricted feeding to better identify phenotypes linked to compulsive behaviors and stress-related dysregulation.

This study identifies sex-specific gene and isoform expression changes in hippocampal aging of rhesus macaques and finds shared transcriptional signatures with Alzheimer's disease.

The paper examines how food and water intake patterns in rats change under light phase restrictions, finding that food access timing more strongly influences water intake than water access timing influences food intake.

This study shows that intestinal epithelial stem cell secretome improves gut repair and cognitive outcomes after stroke in male rats but not in female rats, highlighting the need for sex-specific therapies.

This study identifies inosine triphosphate pyrophosphatase (ITPA) as a candidate factor linking chronic heart failure and white matter abnormalities through human, animal, and cellular analyses.

This study investigates sex-specific effects of hypertension on cerebral hemodynamics and memory, finding that MR antagonism improves perfusion and memory in female rats but not males.

This study compares somitogenesis across human, pig, sheep, and cow stem cell-derived embryo models, revealing species-specific WNT signaling and extracellular matrix requirements for axial segmentation.

This study examines caudate nucleus aging across species and diseases, identifying shared and disorder-specific age-related changes in cell types and regulatory features.

This study shows that RyR2-mediated Ca2+ leak causes arrhythmias and progressive cardiomyopathy in rabbits, identifying RyR2 as a therapeutic target.

This study shows that targeted degradation of long PDE4D isoforms reduces cardiac hypertrophy without affecting contractile function in rat and human cardiomyocytes.

This paper introduces NORIGAMI, a multi-omics pipeline that combines imaging and deep learning to analyze kidney aging, revealing age-related structural and molecular changes.

The paper benchmarks Quantum Barcoding against mass cytometry in human and rhesus macaque blood, integrating data to reveal conserved and divergent signaling responses across species.

This study shows that KIF1A-mediated lysosomal transport into axons is regulated by the axon initial segment microtubule environment, and its disruption leads to axonal degeneration.

The paper compares brain and kidney extracellular vesicle morphology and proteomics after inflammatory challenge, identifying significant protein changes but noting limitations in causal conclusions.

This study shows that neural activity in macaque lateral intraparietal area (LIP) reflects confidence-dependent changes in decision policy, linking confidence to subsequent decision-making.

This study shows that endothelin-2 drives hypertension-related retinal dysfunction through neuroinflammation, independent of intraocular pressure, and identifies EDNRA as a therapeutic target.

The paper maps m6A modifications and polyadenylation events in Plasmodium falciparum mRNAs, identifying stage-specific m6A sites and their potential role in 3' end processing.

This paper identifies Astragalus ginseng as a candidate herb pair for ameliorating chemotherapy-induced ovarian aging using a multi-strategy framework combining single-cell transcriptomics, chemical profiling, and molecular modeling.

This study identifies regulators that control ECA biosynthesis in E. coli, showing ECA's role in acid and reactive nitrogen species stress resistance.

This study shows that neuronal hyperactivity selectively increases tau phosphorylation at S202/T205 in excitatory hippocampal neurons, which reduces GluA2 surface expression and may contribute to Alzheimer's disease pathology.

The paper uses interspecific hybrid embryos to identify EIF1A-family proteins as conserved nuclear regulators of zygotic genome activation across mammals.

This study shows that grooming movements in rhesus macaques are adapted from feeding movements, with similar hand motions used for both tasks.