HIV Research and Treatment

The paper analyzes HIV-1 broadly neutralizing antibodies to classify epitopes and identify potential vaccine candidates based on structural and immunological features.

The paper identifies infant-transmitted HIV-1 variants that are neutralization-resistant to maternal plasma but sensitive to broadly neutralizing antibodies, suggesting maternal antibody responses select for these resistant variants during peripartum transmission.

The paper shows that partial inhibition of HIV transmission can increase live infected lymph node cells by reducing cell death, even with fewer HIV DNA copies per cell.

This study finds that HIV infection is associated with accelerated white matter aging and worse cognitive performance in HIV-positive individuals.

The paper analyzes HIV-1 full-genome sequences from London to reveal high strain variability, including unique recombinants and transmission clusters not detectable with partial sequencing.

This study identifies full-length MHC class I alleles and haplotypes in pig-tailed macaques using Pacific Biosciences sequencing, providing resources for HIV and transplant research.

The paper investigates how structural disorder in the HIV-1 V3 loop correlates with coreceptor switch from CCR5 to CXCR4, finding increased disorder in X4 viruses.

This study shows that CBF-1 maintains HIV latency by recruiting PRC1 and PRC2 to the HIV LTR, and its knockdown or inhibition reactivates latent HIV.

This study shows DNA-PK supports HIV transcription by regulating RNA polymerase II activity and transcription machinery recruitment at HIV LTR, leading to enhanced gene expression and replication.

The paper uses GSEA to analyze gene expression patterns in HIV-infected patients with and without neurocognitive impairments, finding that neuroinflammation and white matter dysfunction precede NCI.

This paper creates a humanized mouse model to study HIV-1's effects on glial cells, finding human-specific transcriptional changes in antiviral responses and myelination.