Mosquito-borne diseases and control

The paper uses comparative genomics to analyze 3’UTR RNA structures in flaviviruses, identifying conserved xrRNAs and duplicated structures across different viral groups.

This paper describes an optimized impression cytology method to obtain viable ocular cells from babies with Congenital Zika Syndrome, enabling transcriptomic and proteomic analyses.

The paper uses genome-wide SNPs to trace the origin of pyrethroid-resistant Aedes aegypti incursions at international ports, identifying Bali and Pacific Islands as key sources.

The paper identifies domains in the Sindbis virus TF protein that regulate its palmitoylation state and its incorporation into virions.

This paper demonstrates that the 5′-UTRs of Dengue and Zika viruses have IRES activity, enabling translation without a cap, and can initiate infection in mammalian and mosquito cells.

This study integrates transcriptomic, proteomic, and genomic data from CZS neonates to identify collagen gene reductions and associated polymorphisms, linking them to neuronal migration defects and CZS susceptibility.

This study generates Ae. aegypti mosquitoes engineered with synthetic miRNAs to reduce ZIKV infection, dissemination, and transmission.

This study infects olive baboons with Zika virus during mid-gestation and observes fetal cerebral cortical injury and fetal death, providing a new non-human primate model for studying Congenital Zika Syndrome.

The paper identifies differentially expressed genes in ZIKV-infected human RNA-seq data and reports significant DEGs potentially involved in altered biological processes.

This study identifies RNA structural elements in ZIKV strains that influence infectivity through comparative in vivo analysis.

The paper presents an improved Aedes aegypti genome assembly, AaegL5, which enhances biological understanding and vector control efforts by resolving key genomic features and identifying new targets for intervention.

The paper identifies and characterizes lncRNAs in Ae. albopictus, showing their differential expression during flavivirus infection and potential roles in antiviral defense.

This study identifies how flavivirus NS3 and NS5 proteins modulate nuclear-cytoplasmic transport and innate immune response by disrupting nuclear pore complexes and relocating nuclear proteins.

This study uses barcoded Zika virus to track genetic bottlenecks during transmission in vitro and in mosquitoes, showing stochasticity in viral dissemination.

The paper demonstrates unbiased sequencing of a pathogen directly from mosquitoes using handheld nanopore sequencing for field-based biosurveillance.

The paper presents an annotated genome assembly of the Aedes albopictus C6/36 cell line, revealing genetic features and gene expression patterns relevant to viral propagation.

This study predicts human-Zika virus protein-protein interactions and designs synthetic peptides to disrupt these interactions as potential anti-Zika virus therapeutics.

This study uses an agent-based model to compare three mosquito-control strategies in spatially heterogeneous settings, finding that spatial heterogeneity significantly affects disease transmission and intervention effectiveness.

This study investigates long-term effects of neonatal ZIKV infection in mice, finding persistent viral replication, brain damage, and behavioral issues despite initial recovery.

The paper identifies abundant viral integrations in Aedes aegypti and Ae. albopictus genomes that express piRNAs, suggesting a functional link to the piRNA pathway and antiviral defense.

This study investigates the transcriptional response to West Nile virus infection in zebra finches, identifying similarities and differences with mammalian immune responses.

This study shows that ZIKV infects neural progenitors, astrocytes, and microglia-like cells, with microglia acting as viral reservoirs and facilitating infection of the fetal brain.

This paper describes a method to sequence Zika and other virus genomes directly from clinical samples using multiplex PCR and portable sequencing technologies, achieving complete genomes in 1-2 days.

This study sequenced 110 Zika virus genomes from 10 countries, revealing rapid expansion in Brazil, multiple introductions into other regions, and undetected circulation before confirmed cases.

The paper analyzes RNA-Seq data from Zika-infected human neural progenitor cells to identify transcriptional changes and isoform divergence in neurodevelopmental pathways.

The paper uses ZIKV genomes to estimate the origin and spread of Zika virus in Brazil and the Americas, providing a timeframe for baseline microcephaly rates.

The paper develops a data-driven model to predict potential Zika virus vectors by analyzing vector-virus trait combinations, identifying 35 species, including seven in the continental US.