Influenza Virus Research Studies

This study evaluates the thermal inactivation of HPAI H5N1 virus in raw milk under various conditions, finding efficient inactivation except for certain thermization protocols.

This paper develops a replicon vaccine against H5N1 influenza that can be administered intranasally or intramuscularly, showing efficacy in reducing morbidity and mortality in a ferret model.

This study shows that influenza virus fusion at the plasma membrane is less efficient than through endosomes, primarily due to differences in membrane composition and order.

This paper develops a live attenuated vaccine candidate, LPhTXdNS1, against H5N1 influenza viruses and shows it is safe, immunogenic, and protective in mice.

The study sampled wild birds in New Zealand and its territories, finding no HPAI H5N1 but detecting H1N9 in red knots during 2023-2024 migration.

This study analyzes the spread of H5 avian influenza in high-density poultry farms using phylogeographic tools, identifying key factors driving transmission and control thresholds.

This study identifies functional determinants in chicken ANP32A that enable species-specific support of avian influenza virus polymerase.

This study analyzes polyclonal and monoclonal antibodies against influenza virus nucleoprotein in different oligomeric states, showing their potential for improving diagnostic technologies.

This study shows that aged lung tissue reduces viral replication of IAV and SARS-CoV-2 but increases inflammatory responses, suggesting immune dysregulation contributes to severe disease.

This study investigates how temperature and pH affect the infectivity of H5N1 avian influenza viruses in dairy products, showing inactivation under certain processing conditions.

The paper assesses the environmental stability of H5N1 influenza virus in raw milk, wastewater, and on surfaces, finding slow decay in milk suggests transmission risks.

This study shows sustained delivery of multivalent influenza vaccines via polymer-nanoparticle hydrogels enhances rapid, consistent, and broad humoral immunity against homologous and heterologous strains.

This study computationally models H5 influenza variants against HA1-neutralizing antibodies, showing weakening antibody binding over time and increased immune evasion risks.

This paper describes CD388, a drug-Fc conjugate that targets influenza virus neuraminidase, showing universal antiviral activity across multiple strains and demonstrating efficacy in mouse models.

This study evaluates the stability of H5N1 virus in raw milk cheese under different pH conditions and finds that the virus persists for up to 60 days at higher pH levels but not at lower pH.

This study develops within-host models to analyze antiviral effectiveness against influenza A H3N2 and SARS-CoV-2 using ferret infection data, finding significant differences in their dynamics and treatment requirements.

This study identifies a PKC-MEK1-ERK2 complex that phosphorylates viral NP, facilitating RNP nuclear export and virus replication.

This study determines the transmissible dose 50% (TD50) for two pandemic influenza viruses in ferrets, showing H3N2 has reduced transmissibility compared to H1N1.

This study shows that caspase cleavage of the Influenza A virus M2 protein disrupts its interaction with LC3, reducing virion production.

The paper reports HPAIV A/H5 infections in skuas along the West Antarctic Peninsula and beyond the Antarctic Polar Circle, linking them to mortalities and marking the southernmost record of such events.

This study identifies amino acid changes in the PB2 protein of H5N1 HPAIV that enhance replication and pathogenicity in human cells and mice.

The paper assesses viral escape from imprinted broad antibody responses using deep mutational scanning of clonal antibody lineages against influenza HA epitopes, showing escape is possible through epistatic networks in drifted strains.

This study evaluates an intranasal influenza vaccine based on neuraminidase (NA) adjuvanted with bacterial membrane-derived components, showing improved immunogenicity and protection against H5N1 challenge.

This study reports the arrival of HPAI H5N1 clade 2.3.4.4b in sub-Antarctic Indian Ocean islands, causing mass mortality in seals and birds, and identifies independent introductions from South Georgia.

This study introduces a statistical framework to estimate the nuclear export rate of influenza viral mRNA segments using imaging data and reveals that hemagglutinin and neuraminidase segments are the slowest.

The paper shows that phylogenetic discordance can overestimate reassortment in avian influenza viruses due to reconstruction errors and suggests methods to reduce false positives.

The paper reports the detection of H5N1 clade 2.3.2.1a avian influenza in domestic cats in India, identifies reassortant viruses, and highlights the need for enhanced surveillance.

The paper identifies NS2-dependent sequence requirements beyond canonical promoters for efficient influenza A virus genome replication, explaining divergent transcriptional dynamics across viral segments.

A single dose of COBRA HA-based inactivated influenza vaccines elicited broadly reactive antibodies and long-term protection against viral challenge in ferrets with pre-existing immunity.