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Topic · Epidemiology · Medicine

Influenza Virus Research Studies

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

7 papers

Identification of HLA-A33-restricted CD8+ T cell epitopes from avian influenza A/H5N1

A. K. M. Muraduzzaman, Patricia T. Illing, Mitchell Jenzen, Nathan P. Croft, Sinéad M. Williams, Paul Selleck, Michelle L. Baker, Katherine Kedzierska, Anthony Wayne Purcell, Nicole A. Mifsud

Immunopeptidomics shows HLA-A*33:01 and HLA-A*33:03 present largely distinct influenza peptide repertoires, and four HLA-A*33:03-restricted epitopes triggered CD8+ T cell responses in A/H5N1-naive donors.

bioRxiv · Jul 13, 2026 · PreprintImmunology✦ In-depth digest

High-throughput neutralization measurements correlate strongly with evolutionary success of human influenza strains

Caroline Kikawa, Andrea N. Loes, John Huddleston, Marlin D Figgins, Philippa L. Steinberg, Tachianna Griffiths, Elizabeth M. Drapeau, Heidi Peck, Ian Barr, Janet A. Englund, Scott E. Hensley, Trevor Bedford, Jesse D. Bloom

A sequencing-based neutralization assay across 78 H3N2 HA strains and 150 sera shows strain growth in 2023 tracks the fraction of sera with low titers, but not pooled-serum titers.

eLife · Feb 23, 2026Peer-reviewedEvolutionary Biology✦ In-depth digest

Investigating high pathogenicity avian influenza virus incursions to remote islands: Detection of H5N1 on Gough Island in the South Atlantic Ocean

Antje Steinfurth, Joshua G. Lynton‐Jenkins, Jaimie B. Cleeland, Benjamin C. Mollett, Holly A. Coombes, Andrea Moores, Robyn Neal, Ben Clifton, Marco Falchieri, Christopher W. Jones, Michelle M. Risi, Susannah Gold, Joe James, Peter G. Ryan, Jenny Solís, Ashley C. Banyard

Whole-genome sequencing and geolocation tracking indicate that high pathogenicity avian influenza H5N1 reached Tristan skuas on remote Gough Island via sub-Antarctic marine networks linked to South Georgia rather than Africa.

Emerging Microbes & Infections · Feb 3, 2026Peer-reviewedPathology✦ In-depth digest

Polymerase mutations underlie early adaptation of H5N1 influenza virus to dairy cattle and other mammals.

Vidhi Dholakia, Jessica L. Quantrill, Samuel A. S. Richardson, Nunticha Pankaew, Maryn D. Brown, Jiayun Yang, Fernando Capelastegui, Tereza Masonou, Katie‐Marie Case, Jila Ajeian, Maximillian N. J. Woodall, Callum Magill, Graham Freimanis, Amy Mccarron, Ecco Staller, , Daniel H. Goldhill

Cattle B3.13 H5N1 polymerase gained PB2 M631L and PA K497R, boosting replication in bovine and human cells via better bovine ANP32A use; later PB2 E627K and D740N add activity.

Nature Communications · Jan 16, 2026Peer-reviewedMicrobiology✦ In-depth digest

Near real-time data on the human neutralizing antibody landscape to influenza virus as of early 2026 to inform vaccine-strain selection

Caroline Kikawa, John Huddleston, Samuel A. Turner, Andrea N. Loes, Jiaojiao Liu, Sydney Gang, Tachianna Griffiths, Elizabeth M. Drapeau, Benjamin John Cowling, Faith C. S. Ho, Nancy Leung, Janet A. Englund, Kirsten Lacombe, Shinji Watanabe, Hideki Hasegawa, , Jesse D. Bloom

Sequencing-based neutralization of 91 H3N2 and H1N1 hemagglutinins against 302 human sera (27,409 titers) shows reduced titers to H3N2 subclade K and H1N1 D.3.1.1.

Virus Evolution · Jan 1, 2026Peer-reviewedMicrobiology✦ In-depth digest

The Haemagglutinin Gene of Bovine Origin H5N1 Influenza Viruses Currently Retains an Avian Influenza Virus phenotype.

Jiayun Yang, Mehnaz Qureshi, Reddy Kolli, Thomas P. Peacock, Jean-Rémy Sadeyen, Toby Carter, Samuel Richardson, Rebecca Daines, William Barclay, Ian Hay Brown, Munir Iqbal

Haemagglutinin of US cattle and goat H5N1 binds only avian-type receptors and fuses at pH 5.9; seven emerging cattle mutations did not switch receptor preference.

Emerging Microbes & Infections · Jan 13, 2025Peer-reviewedMicrobiology✦ In-depth digest