Oral microbiology and periodontitis research

This study uses a synthetic subgingival microbiome model to show that serum intensifies dysbiosis by promoting pathogen growth and altering metabolism.

The paper identifies 'high-risk' clinical isolates of Fusobacterium polymorphum from oral dysplasia patients that show enhanced carcinogenic effects on keratinocytes.

This study identifies significant shifts in the oral microbiome during early pregnancy, showing reduced diversity and a shift toward pro-inflammatory communities, with strong associations with diet and lifestyle factors.

This study compares salivary and plaque microbiomes in children with and without type 1 diabetes, finding saliva provides better classification accuracy for detecting T1D.

This study investigates how socioeconomic status influences the oral microbiome and dental caries risk in Indigenous Australians, finding that income and education significantly affect microbiome composition and that microbiome changes mediate caries risk.

This study conducts a multi-ancestry GWAS on periodontitis using EHR data from the All of Us Research Platform, identifying significant genetic loci associated with periodontitis grade and other phenotypes.

This study shows that Tannerella forsythia's miropin inhibits Porphyromonas gingivalis proteases, reducing its virulence and challenging Tf's role as a pathogen.

This study identifies a candidate pathogenicity island in Fusobacterium nucleatum using bioinformatics and machine learning, linking iron acquisition to cancer promotion.

This study uses 16S rRNA sequencing to identify oral microbiota differences between chronic heart failure patients and healthy controls, finding 14 microbes that can distinguish the two groups with 83.7% diagnostic accuracy.

The paper analyzes metatranscriptomic data to identify condition-specific toxin-antitoxin system expression in oral microbiomes across health and caries states.

This study shows that music can change the oral microbiome in people with age-related cognitive disorders, affecting both the types of microbes and their functions, which are linked to neurodegenerative processes.

The paper identifies CD38⁺ endothelial remodeling as a spatially distinct vasculopathy feature in rapidly advancing oral inflammation using scRNA-seq and spatial proteomics.

The paper constructs a genome-wide CRISPRi library to identify acid tolerance genes in S. mutans and finds 95 associated genes involved in metabolism, tRNA modification, and transcriptional regulation.

This paper develops a cost-effective protocol to enrich 'Ca. Saccharimonadia' from human saliva, enabling high-quality genome sequencing and metagenome-assembled genomes.

This study develops a basal media for carbon utilization assays in Prevotella melaninogenica and identifies a novel starch utilization system.

This study uses shotgun metagenomic analysis of oral saliva from children with noma to identify Treponema sp. A as a novel disease-associated organism and highlights antimicrobial resistance concerns.

This study shows Saccharibacteria suppress epithelial immune activation by clustering TLR2 via Type IV pili and endocytosis, reducing cytokine signaling and enabling long-term persistence in the oral microbiome.

This study evaluates the diagnostic potential of periodontal pathogens and circulating miRNAs for pancreatic cancer, finding a combined model with high predictive accuracy.

This study examines how smoking affects interactions between the oral microbiome, metabolism, and psychological traits using multi-omics datasets and network analysis.

The paper reports the complete genome sequences of eight clinical isolates of Fusobacterium watanabei and classifies them within the 'Fusobacterium nucleatum_J' group.

This study models how Fusobacterium nucleatum induces epithelial oncogenic transformation through the FadA-lactate-angiogenesis pathway, identifying lactate accumulation and VEGF upregulation as key factors in cancer progression.

This study shows that the S. mutans LiaS gene regulates cross-kingdom interactions with C. albicans, reducing hyphal formation and biofilm production in dual-species infections.

This study shows carvacrol hydrogel promotes alveolar bone repair by activating the PI3K pathway and reducing inflammation in periodontal disease.

This study investigates the relationship between demographic factors, S. mutans colonization, and early childhood caries risk in preschool children from northern Arizona and Hawaii.

This study characterizes Fusobacterium nucleatum isolates from oral squamous cell carcinoma patients and non-cancer individuals, revealing differences in virulence traits and cancer cell interactions.

This study examines the link between close-range proximity and oral microbiota similarity in children, finding that more time spent in proximity correlates with greater microbiota similarity.

This study identifies HDAC6's role in regulating FoxO1 acetylation and phosphorylation to control periodontal inflammation, showing reduced inflammation and bone loss in HDAC6-deficient models.

This study investigates sex-specific differences in periodontitis progression, finding that neutrophil inflammation drives sexual dimorphism in bone loss.

This study identifies microbial dysbiosis in OSCC tissues of Sri Lankan male patients with oral risk habits, highlighting specific pathogens and their associations with oral cancer.

This study identifies interpain A (InpA) from Prevotella intermedia as a protease that promotes oral squamous cell carcinoma cell proliferation and migration via PAR-2 signaling.