Oral microbiology and periodontitis research

Neutrophil-Derived Oncostatin M Contributes to Endothelial Cell Dysfunction During Treponema denticola interaction

This study shows that neutrophil-derived oncostatin M (OSM) contributes to endothelial dysfunction during Treponema denticola infection, linking periodontitis to cardiovascular disease.

Bacterial metagenome in plaque, saliva, and tumor samples from individuals with and without OSCC by next-generation sequencing

The paper uses shotgun metagenomic sequencing to compare bacterial communities in plaque, saliva, and tumor samples from OSCC patients and healthy controls, identifying distinct microbial profiles.

Comparison of oral and gut microbiome highlights role of oral bacteria in systemic inflammation in HIV

This study compares oral and gut microbiomes in HIV patients and finds oral bacteria like Veillonella parvula contribute to systemic inflammation through epithelial barrier disruption and monocyte activation.

Polymicrobial-driven NLRP6 inflammasome regulates IL-1β production and alveolar bone loss in a murine model of periodontitis

This study shows that NLRP6 inflammasome activation by polymicrobial interactions drives IL-1β production and alveolar bone loss in a mouse model of periodontitis.

Paired oral clinical specimens reveal the underlying ecology supporting the emergence of inflammophilic microbiome communities

The paper investigates how host inflammation reshapes oral microbiome communities by analyzing paired clinical specimens and identifying metabolic shifts associated with inflammatory states.

High-resolution taxonomic profiling and metatranscriptomics identify microbial, biochemical, host and ecological factors in peri-implant disease

Myeloid-derived Suppressor Cells Mitigate Inflammation in Periodontal Disease

This study shows that MDSCs reduce inflammation and protect bone in periodontal disease by suppressing T cells and promoting regulatory T cells.

Dental calculus formation is linked to diet and phylogeny in mammals

This study examines dental calculus presence across 142 mammalian species to identify diet and phylogeny factors influencing its formation.

Genomic instability and biofilm determinants in Streptococcus mutans: insights from a sequence-defined arrayed transposon library

This paper identifies novel biofilm determinants in Streptococcus mutans using an arrayed transposon library and highlights genomic instability in the library that risks misattributing gene functions.

Ancient species diversity and niche adaptation in Tannerella and Porphyromonas revealed through pangenomics

This study uses pangenomics and phylogenetics to analyze ancient and modern bacterial genomes of Tannerella and Porphyromonas, revealing new species, niche adaptations, and geographic patterns in oral microbiota.

Interindividual differences in caries potential of the salivary microbiome after mouthwash exposure

This study evaluates the effect of three fluoride mouthwashes on the salivary microbiome and finds that Meridol has the best anticaries potential, with flow cytometry capturing treatment response.

Population-scale Characterization of the Oral Microbiome and Associations with Metabolic Health

This study characterizes the oral microbiome across 9,431 participants and identifies associations with metabolic health, finding specific microbial features linked to metabolic traits and disease classification.

Longitudinal Dynamics and Site-Specific Recovery of the Human Respiratory Microbiome Following Smoking Cessation

This study tracks respiratory microbiome changes in smokers after cessation, showing site-specific recovery and persistent microbial alterations.

Novel small molecule targeting PgQC reduces Porphyromonas gingivalis virulence

This study identifies S-0636, a small molecule inhibitor of PgQC, which reduces Porphyromonas gingivalis virulence without killing the bacteria or causing resistance.

The oral cavity of chronically homeless adults is home for unusual extremophile environmental bacteria

This study characterizes the oral microbiota of chronically homeless adults in Mexico City, finding higher bacterial diversity and the presence of extremophile bacteria not typically found in humans.

Unique ecology of co-occurring functionally and phylogenetically undescribed species in the infant oral microbiome

The paper identifies two previously unknown oral bacteria in infants and shows they co-occur and exchange nutrients through metabolic interactions.

Oral Microbiota Composition in Children and Adults During Spanish COVID-19 Lockdown: Impact of Home Self-Confinement and SARS-CoV-2 infection

This study examines how oral microbiota composition in children and adults changes during the COVID-19 lockdown, finding age and cohabitation influence microbiota, but not infection status in children.

Ecological and Stochastic Determinants of the Growth and Persistence of the Oral Pathogen Porphyromonas gingivalis

The paper identifies ecological and stochastic factors influencing the growth and persistence of Porphyromonas gingivalis using mathematical modeling and experimental data.

Human and bacterial genetic variation shape oral microbiomes and health

The paper identifies 11 human genetic loci associated with oral microbiome composition and host-microbial interactions linked to tooth decay.

Integrative multi-omic analysis reveals oral microbiome-metabolome signatures of obesity

This study identifies oral microbiome and metabolome signatures associated with obesity through a multi-omics analysis of 192 matched samples from 628 Emirati adults.

Cross-feeding interactions between Fusobacterium nucleatum and the glycan forager Segatella oris

This paper investigates bidirectional cross-feeding interactions between Fusobacterium nucleatum and Segatella oris, showing how glycan degradation and microbial antagonism influence bacterial physiology and host responses.

Comparative Characterization Reveals Conserved and Divergent Ecological Traits of Oral Corynebacteria

This study compares two new oral corynebacterial strains with reference strains to reveal differences in biofilm formation, metabolic capacity, and interspecies signaling.

The Porphyromonas gingivalis lipid A 1-phosphatase LpxE has unique features and requires a functional type IX secretion system for its activity

This study investigates the role of T9SS OMPs in OMV biogenesis and shows that LpxE, a lipid A 1-phosphatase, requires these proteins for activity and correct vesicle formation.

Effect of a bacterial Glutaminyl Cyclase inhibitor on multi-species-biofilms

This study evaluates a bacterial Glutaminyl Cyclase inhibitor's effect on multispecies biofilms, showing reduced metabolic activity and virulence factors without affecting bacterial counts.

Functional characterization and optimization of protein expression in Treponema denticola shuttle plasmids

This paper characterizes and optimizes gene expression in a shuttle plasmid for Treponema denticola, highlighting the importance of promoter-gene pairing for efficient protein expression.

Periodontopathogens interfere with the human renin-angiotensin system through a surface-attached protease

This study shows that oral pathogens Porphyromonas gingivalis and Tannerella forsythia use surface-attached proteases to alter the renin-angiotensin system by generating Ang 1-7.

Unraveling novel insights into dual-species cariogenic biofilm formation: a comparative analysis on natural vs artificial bioengineered dentin models

This study compares dual-species biofilm formation on bioengineered and natural aged dentin, showing similar biofilm patterns and viability, validating the engineered model as a reliable platform for cariogenic biofilm research.

A high-quality genomic catalog of the human oral microbiome broadens its phylogeny and clinical insights

The paper presents a high-quality genomic catalog of the human oral microbiome, revealing novel species and highlighting its clinical relevance to systemic diseases.

Characterising the periodontal granulation tissue using scRNAseq.

This study uses scRNA-seq to characterize periodontal granulation tissue, identifying novel cell populations and pathways involved in disease pathogenesis and regenerative potential.

Tyrosine phosphorylation coupling of one carbon metabolism and virulence in an endogenous pathogen

This study shows that tyrosine phosphorylation regulates the coupling between one carbon metabolism and virulence in Porphyromonas gingivalis by controlling gingipain protease localization and activity.