Cancer Cells and Metastasis

Neuro-mimetic reprogramming and epigenetic unlocking drive lung cancer stem cell adaptation to the brain microenvironment

This study shows lung cancer stem cells adapt to the brain microenvironment through neuro-mimetic reprogramming and epigenetic changes, enabling metastasis.

Tumour architecture inverts ARNT-dependent growth regulation and reveals CPE-mediated spheroid expansion in luminal breast cancer

This study shows that ARNT's role in breast cancer growth changes with tumor architecture, with CPE mediating spheroid expansion in luminal breast cancer.

Cancer cell adaptations along a proliferation-robustness axis drive TME pro-tumor phenotypes

The paper shows cancer cells adapt along a proliferation-robustness axis in response to TME components, leading to pro-tumor phenotypes.

CDH1 loss remodels gene expression and lineage identity in human mammary epithelial cells

This study shows that CDH1 loss in human mammary epithelial cells remodels gene expression and lineage identity toward a luminal progenitor-like state, contributing to ILC oncogenesis.

Comparative characterization of OncoPro™ and Wnt-Based media reveals distinct phenotypic and pharmacologic states in patient-derived tumor organoids

This paper compares OncoPro™ and Wnt-based media in patient-derived tumor organoids, finding distinct phenotypic, transcriptomic, and pharmacologic differences.

Immune-Epithelial Interactions via TGF-β Orchestrates Stem-Cell Niche Formation and Morphogenesis

This study shows immune cells influence stem-cell niche formation and organoid development through TGF-β signaling in a 3D breast organoid model.

Droplet-based organoid screens enable high-throughput identification of cancer vulnerabilities

This paper introduces a droplet-based organoid culture method for high-throughput screening of cancer vulnerabilities, identifying novel therapeutic targets in stomach cancer.

Matrix-modulated Air-liquid Interface Microenvironments Reveal Architectural Control of Lung Tumor Phenotypes

This study shows that combining air-liquid interface, extracellular matrix, and 3D architecture in vitro models produces distinct lung tumor phenotypes not seen in standard 2D or submerged 3D cultures.

Malignant and stromal partial EMT programmes and cetuximab outcome in head and neck cancer

The paper identifies malignant and stromal partial EMT programs in head and neck cancer and shows that malignant measures correlate with better cetuximab outcomes.