Chronic Kidney Disease and Diabetes

Multimodal single cell sequencing of human diabetic kidney disease implicates chromatin accessibility and genetic background in disease progression

This study uses multimodal single-cell sequencing to show that chromatin accessibility and genetic background influence diabetic kidney disease progression through cell-specific mechanisms.

Proteomic analysis of mouse kidney tissue associates peroxisomal dysfunction with early diabetic kidney disease

The paper identifies peroxisomal dysfunction as a key feature of early diabetic kidney disease through proteomic analysis in mice and human samples.

Collagen Deposition in Diabetic Kidney Disease Boosts Intercellular Signaling: A Mathematical Model

The paper develops a mathematical model to study how collagen deposition in diabetic kidney disease affects intercellular signaling, finding that it can enhance signaling range rather than diminish it.

HBA Copy Number and Kidney Disease Risk among Black Americans: a Longitudinal Cohort Study

This study examines the association between HBA copy number and kidney disease risk in Black Americans, finding higher HBA copy number linked to increased CKD prevalence and ESKD incidence.

Reversal of the renal hyperglycemic memory by targeting sustained tubular p21 expression

The paper identifies p21 as a key mediator of hyperglycemic memory in diabetic kidney disease and shows that aPC signaling can reverse its effects.

DsbA-L protects against diabetic renal injury through the adipo-renal axis

This study shows that overexpressing DsbA-L in adipose tissue protects against diabetic kidney damage by reducing inflammation and improving kidney function through the adipo-renal axis.

Characterisation of the Renal Cortical Transcriptome Following Roux-en-Y Gastric Bypass Surgery in Experimental Diabetic Kidney Disease.

This study shows that Roux-en-Y Gastric Bypass Surgery reduces renal injury in diabetic rats by altering fibrosis, inflammation, and TGF-β pathways in the kidney.

Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy

This study investigates the role of GPR109a in diabetic nephropathy by examining its effects on renal injury and intestinal permeability in Gpr109a-/- mice.

MiR-9-5p protects from kidney fibrosis by metabolic reprogramming

The paper shows miR-9-5p protects against kidney fibrosis by reprogramming metabolism and mitochondrial function in a mouse model.

The Single Cell Transcriptomic Landscape of Early Human Diabetic Nephropathy

This study uses snRNAseq to analyze early diabetic nephropathy in human kidneys, identifying gene expression changes in potassium secretion and angiogenic signaling across multiple cell types.

Emodin Attenuates Renal Interstitial Fibrosis via Regulation of TIMP1/MM9 Pathway in Rats

This study shows emodin reduces renal interstitial fibrosis in rats by modulating the TIMP1/MM9 pathway.

Genome-wide association study of diabetic kidney disease highlights biology involved in renal basement membrane collagen

This study identifies 16 genome-wide significant loci associated with diabetic kidney disease, including a protective variant in the COL4A3 gene.

Exome-wide association study on Albuminuria identifies a novel rare variant in CUBN and additional genes, in 33,985 Europeans with and without diabetes

Progression of chronic kidney disease in African American with type 2 diabetes mellitus using topology learning in electronic medical records

This study uses EMRs and GWAS data to map CKD progression trajectories in African Americans with type 2 diabetes, identifying high-risk and low-risk pathways linked to APOL1 genotypes.