Chronic Kidney Disease and Diabetes

Elevated glucose in kidney organoids induces tissue-intrinsic inflammation driving epithelial detachment

This study shows that high glucose in kidney organoids causes inflammation and epithelial detachment, which can be reversed by targeting cytokines and signaling pathways.

Ageing impacts extracellular matrix turnover and remodelling in the kidney

This study quantifies age-related changes in kidney extracellular matrix turnover and identifies structural and functional alterations linked to fibrosis.

Multimodal predictions of end stage chronic kidney disease from asymptomatic individuals for discovery of genomic biomarkers

The paper predicts end-stage renal disease from asymptomatic individuals using multimodal data and identifies novel genomic biomarkers associated with kidney function and disease risk.

A MEF2C transcription factor network regulates proliferation of glomerular endothelial cells in diabetic kidney disease

This study identifies a MEF2C transcription factor network that regulates endothelial cell proliferation in diabetic kidney disease and shows that SGLT2i treatment can reverse its dysregulation.

Artesunate Alleviate Kidney Fibrosis by Restoring Klotho Protein and Suppressing Wnt/β-Catenin Signalling Pathway

This study shows artesunate reduces kidney fibrosis by restoring Klotho protein and inhibiting the Wnt/β-catenin pathway in both mouse and human models.

Multi-Cellular Network Model Predicts Alterations in Glomerular Endothelial Structure in Diabetic Kidney Disease

This study uses a logic-based network model to predict how glucose signaling dysregulation affects glomerular endothelial cell fenestrations in diabetic kidney disease.

A murine model of cardiovascular-kidney-metabolic syndrome demonstrates compromised limb function in the ischemic hind limb

This study develops a murine model of cardiovascular-kidney-metabolic syndrome by combining high-fat and adenine diets, showing impaired limb function and metabolic complications.

SGLT2 Inhibition Ameliorates Age-Dependent Renovascular Rarefaction

This paper shows that SGLT2 inhibition reduces age-related vascular rarefaction and preserves renal function in African turquoise killifish.

The non-steroidal mineralocorticoid receptor (MR) antagonist (FINERENONE) reverses Western diet-induced kidney disease by enhancing mitochondrial metabolism and decreasing lipid accumulation and inflammation

This study shows that Finerenone reduces kidney disease in mice by improving mitochondrial function, lowering lipid accumulation, and reducing inflammation.

D-glucuronyl C5-epimerase binds to EGFR to suppress kidney fibrosis

This study identifies Glce as a key regulator of kidney fibrosis by binding to EGFR and inhibiting EMT through the TGF-β/Smad pathway, independent of its enzymatic activity.

Microbes regulate glomerular filtration rate in health and chronic kidney disease in mice

This study shows that gut microbes regulate glomerular filtration rate (GFR) in mice, with their suppression increasing GFR in both healthy and chronic kidney disease models.

Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progression

This paper uses time-resolved multi-omics analysis of kidney fibrosis to identify novel mechanisms and validate transcription factors involved in collagen deposition.

Intersecting Transcriptomic Landscapes of Hypertension and Kidney Function in African American Women

This study identifies 95 female-specific genes associated with hypertension and kidney function in African American women through transcriptomic analysis.

Logic-Based Modeling of Inflammatory Macrophage Crosstalk with Glomerular Endothelial Cells in Diabetic Kidney Disease

The paper develops a logic-based ODE model to study inflammatory crosstalk between macrophages and glomerular endothelial cells in diabetic kidney disease, identifying key signaling molecules and interactions affecting endothelial dysfunction.

Gucy1α1 specifically marks kidney, heart, lung and liver fibroblasts

The paper identifies Gucy1α1 as a specific marker for fibroblasts in multiple organs, showing its expression increases in fibrotic conditions across mouse and human tissues.

A Mathematical Model of Glomerular Fibrosis in Diabetic Kidney Disease to Predict Therapeutic Efficacy

The paper develops a mathematical model of glomerular fibrosis in diabetic kidney disease to predict therapeutic efficacy and identify ineffective treatments.

Proteomic analysis identifies dysregulated proteins in albuminuria: a South African pilot study

The paper identifies dysregulated proteins in urine from individuals with albuminuria and preserved GFR, linking them to pathways involved in IGF, immunity, and extracellular matrix organization.

Spatial proteomics of human diabetic kidney disease, from health to class III

The paper uses spatial proteomics to analyze protein expression changes in human diabetic kidney disease across different stages, revealing compartment-specific cellular and inflammatory changes.

Trajectories of atherosclerotic cardiovascular disease risk scores as a predictor for incident chronic kidney disease

This study shows that increasing atherosclerotic cardiovascular disease risk scores predict incident chronic kidney disease over time in a Korean cohort.

Single-cell transcriptomics reveals a mechanosensitive injury signaling pathway in early diabetic nephropathy

This study uses single-cell RNA sequencing to identify a mechanosensitive MRTF-SRF pathway in early diabetic nephropathy, validated in human datasets and ex vivo experiments.

Urine-based detection of biomarkers indicative of chronic kidney disease in a patient cohort from Ghana

The paper identifies gender-specific and gender-independent cytokine markers in urine from Ghanaian CKD patients, suggesting potential biomarkers for early detection.

A Polygenic Score for Reduced Kidney Function and Adverse Outcomes in a Chronic Kidney Disease Cohort

The paper assesses if a polygenic score for reduced kidney function predicts adverse outcomes in chronic kidney disease patients, finding significant associations but no improvement in prediction over existing risk equations.

Genome-wide meta-analysis and omics integration identifies novel genes associated with diabetic kidney disease

Alterations in protein translation and carboxylic acid catabolic processes in diabetic kidney disease

The paper identifies altered protein translation and carboxylic acid catabolism in diabetic kidney disease using human and mouse models.

Systems and classical biology approaches unraveled role of olfactory receptors in progression of kidney fibrosis

The paper identifies changes in olfactory receptor expression during kidney fibrosis progression using systems biology and experimental validation in a mouse model.

Proteomic analysis of mouse kidney tissue associates peroxisomal dysfunction with early diabetic kidney disease

The paper identifies peroxisomal dysfunction as a key feature of early diabetic kidney disease through proteomic analysis in mice and human samples.

Collagen Deposition in Diabetic Kidney Disease Boosts Intercellular Signaling: A Mathematical Model

The paper develops a mathematical model to study how collagen deposition in diabetic kidney disease affects intercellular signaling, finding that it can enhance signaling range rather than diminish it.

HBA Copy Number and Kidney Disease Risk among Black Americans: a Longitudinal Cohort Study

This study examines the association between HBA copy number and kidney disease risk in Black Americans, finding higher HBA copy number linked to increased CKD prevalence and ESKD incidence.

Characterisation of the Renal Cortical Transcriptome Following Roux-en-Y Gastric Bypass Surgery in Experimental Diabetic Kidney Disease.

This study shows that Roux-en-Y Gastric Bypass Surgery reduces renal injury in diabetic rats by altering fibrosis, inflammation, and TGF-β pathways in the kidney.

Exploring the role of the metabolite-sensing receptor GPR109a in diabetic nephropathy

This study investigates the role of GPR109a in diabetic nephropathy by examining its effects on renal injury and intestinal permeability in Gpr109a-/- mice.