Traumatic Brain Injury Research

This study investigates how repetitive mild traumatic brain injury (rmTBI) affects risk/reward decision making and catecholamine regulation in the prefrontal cortex, revealing sex-specific and time-dependent changes.

This study finds that female children with concussions show greater post-injury internalizing and externalizing behavior problems, linked to disrupted white matter maturation.

The paper examines how concussion affects connectivity within and between brain networks, linking these changes to symptoms and cognitive performance in athletes.

This study identifies distinct spectral profiles in resting EEG of PDOC patients using frequency and topography analysis, which correlate with neurobehavioral capacity and diagnosis.

This study examines electrophysiological changes in hippocampal neurons and their subtypes in a porcine model of concussion, finding altered properties in interneurons and hyperexcitability in pyramidal neurons.

This study conducts a genome-wide association study (GWAS) of traumatic brain injury (TBI) in U.S. military veterans, identifying 15 genome-wide significant loci and showing genetic correlations with psychiatric traits.

This study investigates sex and estrous cycle differences in mild TBI effects on anxiety and fear conditioning in rats, finding progesterone does not mitigate psychological symptoms.

This study investigates how prolonged stress and sex differences affect sleep-wake dysfunction in mice following repetitive mild traumatic brain injury.

This study performs sex-stratified RNA-seq analysis of TBI-affected brain regions and identifies female-specific gene modules linked to dementia in TBI donors.

This study shows that inhibiting the integrated stress response (ISR) after concussive injury reverses cognitive deficits and aberrant cortical spine dynamics in mice.

This study shows that repeated mild traumatic brain injuries (rmTBI) cause time- and location-dependent changes in cranial bone structure in rats, specifically increasing bone thickness and reducing marrow cavity volume in the interparietal bone.

This study shows that repetitive mTBI causes LHb neuronal dysfunction, leading to motivational deficits, and that inhibiting LHb activity can reverse these deficits.

The paper simulates cortical spreading depolarization (SD) to determine optimal EEG electrode spacing for non-invasive detection of SD in concussion.

This study finds that thalamo-prefrontal connectivity, assessed via DTI, predicts early command-following after severe TBI with 72% accuracy.

This study investigates how repeated blast TBI and oxycodone self-administration interact to affect neuroimaging outcomes and drug seeking behavior in rats.

This study finds that reduced temporal lobe activation for faces and scenes predicts episodic memory deficits after traumatic brain injury, despite normal behavioral performance.

This study examines cerebrovascular responses to breath-hold challenges in patients with chronic mild traumatic brain injury using respiratory gas exchange metrics and fMRI.

This paper introduces an LSTM-based classifier that accurately distinguishes acute concussions from healthy states using raw resting state EEG data from adolescent athletes.

This study examines cognitive-motor function in women with IPV-related brain injury using the OHA task, finding BI load and comorbidities significantly affect performance.

This study identifies molecular and cellular changes in oligodendrocytes and astrocytes in CTE using single-nucleus RNA sequencing and histological analysis.

This study shows that repetitive mild head trauma in Drosophila causes long-term brain deficits, worsened in females, and links increased neuronal activity to chronic degeneration.

This study investigates how traumatic brain injury affects working memory by analyzing neural activity patterns during different cognitive load conditions.

The paper examines the association between diffusion MRI metrics and blood biomarkers in adolescent athletes, finding links between Tau levels and microstructural changes in the corpus callosum.

This study shows that repetitive blast exposure in mice leads to chronic aversive responses to environmental cues, unlike single exposures, highlighting the complex effects of repeated trauma.

The paper identifies neural markers of anxiety vulnerability after traumatic brain injury by analyzing molecular profiles in vulnerable mice.

The paper examines the relationship between EEG power spectra, subcortical damage, and consciousness disorders, showing how combining EEG, clinical, and MRI data can improve diagnosis.

This study shows that severe head injury or repetitive subconcussive impacts in rats lead to prolonged headache-like behaviors, which can be reduced by anti-CGRP treatment.

This study introduces a lesion correction method for cortical volumetric analysis in TBI patients, improving accuracy and enabling inclusion of lesioned brains in network-based analyses.

This study compares information flow patterns in healthy and concussed adolescents using EEG data, finding altered flow patterns and distribution in the concussed group.