Reproductive tract infections research

This study identifies Prevotella as a major source of sialidases in the vaginal microbiome, showing their prevalence and activity compared to Gardnerella.

This study infects human intestinal organoids with Chlamydia trachomatis, showing resistance to apical infection and basolateral entry, and identifies Pgp3 as a key virulence factor.

This study identifies P. timonensis as a BV-associated bacterium with high mucin-degrading enzyme activity that removes protective glycocalyx sugars from vaginal epithelium.

This study identifies oleic acid as a compound that inhibits L. iners and promotes L. crispatus growth, offering a potential new treatment strategy for bacterial vaginosis.

This study shows that ectopic expression of the chlamydial transcriptional regulator Euo arrests developmental progression at an early Intermediate Body stage but does not affect the formation of the infectious Elementary Body.

This study identifies two short linear motifs in Chlamydia effector IncE that reprogram host vesicle trafficking to support bacterial replication.

This paper develops a qRT-PCR test targeting 22 BV-associated species and uses it to create a diagnostic index that classifies vaginal microbiome states into BV-positive, BV-negative, or transitional BV.

This paper identifies the interaction between Chlamydia trachomatis effector Tri1 and host TRAF7, showing Tri1 displaces TRAF7's native binding partners to alter its signaling during infection.

This study investigates how Neisseria gonorrhoeae colonizes macrophages under different polarization states and nutrient conditions, finding that invasion occurs across all activation states with lower efficiency in M1-like macrophages.

This study links affective symptoms during pregnancy to vaginal microbiome composition, showing associations with specific taxa and metabolic pathways.

This study analyzes longitudinal vaginal microbiome data from diverse ethnic groups, revealing ethnic signatures in microbial diversity, community states, and evolutionary dynamics, with Lactobacillus adhesins showing positive selection.

This study analyzes genomic variation in Chlamydia trachomatis serovars A and B from Gambian trachoma-endemic villages to understand strain diversification and evolutionary pressures.

This study uses neural differential equations to predict preterm birth from vaginal microbiota data, achieving better performance than traditional machine learning methods.

This study shows that female sex hormones regulate vaginal microbiota colonization in mice, with estrogen promoting bacterial persistence and glycogen production.

This study profiles the vaginal microbiome of Chinese women during pregnancy and 6 weeks postpartum, identifying variations linked to medical history and pregnancy outcomes.

The paper characterizes the vaginal microbiome and sialidase activity in 2689 Chinese pregnant women, finding no association with preterm birth risk.

This study uses microbial topic modeling to identify associations between vaginal microbiome composition and intrapartum fever in Ugandan laboring women, improving prediction beyond clinical variables.

The paper predicts bacterial carbohydrate-binding proteins (lectins) across genomes to explore their role in vaginal microbiome colonization and pathogenicity.

The paper improves whole-genome sequencing of Chlamydia trachomatis from clinical samples by redesigning an RNA bait library, achieving 100% efficiency and identifying genomic recombination in paired specimens.

The paper analyzes genomic variation in Chlamydia trachomatis from Ethiopia to assess its role in continued transmission after SAFE interventions.

The paper uses scRNA-Seq to analyze early host cell responses to Chlamydia trachomatis infection, identifying distinct transcriptional patterns and potential biomarkers.

The paper reports an outbreak of Chlamydia trachomatis caused by a hybrid L2b/D-Da strain with a unique genome that combines virulence features of LGV and non-LGV strains.

This study shows that Medroxyprogesterone Acetate (MPA) increases vaginal microbiota diversity and reduces glycogen and amylase, which correlates with increased HIV-1 susceptibility in Kenyan sex workers and humanized mice.

This study traces the evolutionary divergence of Neisseria gonorrhoeae by analyzing global isolates, linking antimicrobial use to the emergence of two distinct lineages with different resistance strategies.

The paper identifies genetic pathways associated with Chlamydia trachomatis serological response and finds overlap in pathway associations between ocular and urogenital infections.

The paper analyzes Ct genomic diversity and identifies SNPs associated with ocular localization and disease severity in a West African trachoma-endemic population.

This paper evaluates a commercial real-time PCR assay for detecting Chlamydia trachomatis in ocular swabs, finding good sensitivity but lower specificity compared to other tests.