Microtubule and mitosis dynamics

The paper identifies proteins required for cohesion rejuvenation during meiotic prophase in Drosophila oocytes using an RNAi screen, finding Brahma and Pumilio as key regulators.

This study identifies CEP41 as a microtubule-stabilizing protein that regulates microtubule assembly and cell proliferation, with implications for ciliopathies.

The paper shows TANGLED1 is recruited to cell plate fusion sites independently of the preprophase band during cytokinesis in maize.

This study identifies KKT14-KKT15 in kinetoplastids as divergent orthologs of Bub1/BubR1-Bub3, suggesting a unique mechanism for chromosome segregation fidelity in trypanosomes.

The paper investigates how molecular torques balance spindle twist during anaphase in human cells, identifying factors that increase or decrease twist.

This study uses MINFLUX to analyze kinesin-1 dynamics in neurites, identifying ATP-binding states and microtubule switching behavior.

The paper investigates the effects of chronic SAC activation in mice, finding it causes bone marrow aplasia and intestinal atrophy, with BIM playing a critical role in gastrointestinal cell death.

The paper shows that katanin, kinesin-13, and ataxin-2 prevent premature interaction between maternal and paternal genomes in C. elegans zygotes by limiting sperm content movement and maintaining cohesion.

This study shows that nitrogen availability and TOR signaling improve mitotic fidelity in fission yeast, even when lipid metabolism is disrupted, by mechanisms unrelated to lipid restoration.

The paper shows FOXM1 and CENP-F coordinately regulate G2/M gene expression, specifically affecting chromosome stability in cancer cells.

The paper investigates the role of epsilon tubulin (TUBE1) in microtubule-based structures during male germ cell development in mice, showing its essential function and link to male sterility.

The paper identifies a communication hub involving Mps1 and Aurora B kinases that regulates kinetochore-microtubule attachment through interactions with Ndc80c and Dam1c.

This study examines microtubule reorganization during mitosis in the dinoflagellate Ostreopsis cf. ovata, revealing unique features of cell division and a cytokinetic mechanism independent of the actomyosin ring.

The paper shows that Ipl1/Aurora B kinase regulates Mps1's release from kinetochores by competing with Dam1 for binding to Ndc80:Nuf2, enabling proper chromosome segregation.

This study shows that CnSlu7 ensures proper nuclear positioning during mitosis in Cryptococcus neoformans by regulating splicing of cell cycle and cytoskeletal genes.

This study shows that phosphatidic acid recruits specific motor proteins to lipid bilayers, enabling in-vitro motility and revealing mechanisms of cargo transport and direction reversal.

This paper identifies ADP release as a rate-limiting factor in kinesin-microtubule binding using experimental data and computational models.

The paper identifies ST-401 as an interphase-specific killer of cancer cells that prevents the formation of polyploid giant cancer cells.

The paper identifies that MARK2 phosphorylates KIF13A to regulate dendritic transport of transferrin receptor-containing vesicles by promoting dissociation from vesicles and preventing axonal transport.

The paper shows that centrosome age causes subtle spindle asymmetry in symmetrically dividing cells, leading to unequal daughter cell sizes.

The paper identifies PIE-1 and POS-1 as germ fate determinants that protect P2 germ precursor cells from cytokinesis failure by reducing septin and anillin levels at the division plane.

This study investigates the functional differences between VPS4A and VPS4B in cytokinetic abscission, revealing distinct roles for monomeric VPS4A and its co-factor VTA1.

The paper shows that long chromosomes experience delayed error correction during mitosis due to increased polar ejection force, which can falsely stabilize incorrect attachments.

This study identifies the YY2/BUB3 axis as a regulator of SAC activity and shows how SAC hyperactivity and CIN levels influence tumor cell fate and drug sensitivity.

The paper reports the structure of the γ-tubulin ring complex-capped microtubule, revealing how it nucleates and stabilizes 13-protofilament microtubules.

This study shows that long-term actin cytoskeleton dysregulation leads to compensatory changes in microtubules and intermediate filaments in neuronal processes, affecting transport and mimicking neurodegenerative disease features.

The paper identifies how nutrients regulate the Mitotic Exit Network (MEN) in budding yeast by modulating cell growth and phosphorylation of MEN components.

This study shows that KATANIN-mediated microtubule severing is essential for forming and functioning MTOCs in the liverwort Marchantia polymorpha.

This study investigates the role of PfCAP-H in condensin I complex assembly and karyokinesis during Plasmodium falciparum asexual proliferation, finding it essential for structural integrity and proper cell division.