Stroke Rehabilitation and Recovery

Females versus males exhibit greater brain activation in sensorimotor regions during motor imagery after stroke

This study finds sex differences in brain activation during motor imagery after stroke, with females showing greater sensorimotor activation and males greater cerebellar and parietal activation.

Use of the non-paretic arm reflects a habitual behaviour in chronic stroke

This study shows that chronic stroke survivors habitually use their non-paretic arm even when it is less beneficial, especially under time pressure.

Patterns of Structural Disconnection Driving Proprioceptive Deficits After Stroke

This study identifies white matter disconnection patterns linked to proprioceptive deficits after stroke using CLSM and kinematic assessments in chronic stroke survivors.

Proportional recovery in mice with cortical stroke

This study applies the Proportional Recovery Rule to mice with cortical stroke, finding two recovery clusters and higher recovery in one cluster compared to human studies.

Reinforcement Learning Is Impaired in the Sub-acute Post-stroke Period

This study finds that reinforcement learning is impaired in the sub-acute post-stroke period, while error-based learning remains unaffected, suggesting the need for adjusted rehabilitation strategies.

Identification of distinct subtypes of post-stroke and neurotypical gait behaviors using neural network analysis of kinematic time series data

This paper identifies distinct subtypes of post-stroke and neurotypical gait behaviors using neural network analysis of kinematic time series data, revealing five clusters with unique kinematic patterns.

A global effort to benchmark predictive models and reveal mechanistic diversity in long-term stroke outcomes

This study benchmarks predictive models for long-term stroke outcomes using a global consortium, revealing mechanistic diversity and key predictors across motor, cognitive, and emotional domains.

Impairments in proprioceptively-referenced limb and eye movements in chronic stroke

This study examines how proprioceptive impairments in the upper limb affect eye movement accuracy in stroke survivors, finding a strong correlation between hand and eye proprioceptive errors.

Force variability is a potential biomarker of motor impairment in hemispheric stroke survivors

This study finds that force variability increases on the paretic side during specific motor tasks in stroke survivors, suggesting it could be a biomarker for motor impairment severity.

Explicit and implicit locomotor learning in individuals with chronic hemiparetic stroke

This study compares explicit and implicit locomotor learning in individuals with chronic stroke to neurologically intact controls, finding deficits in both processes.

Combining Gamma Neuromodulation and Robotic Rehabilitation Restores Parvalbimin-mediated Gamma Function and Boosts Motor Recovery in Stroke Mice

This study combines gamma neuromodulation and robotic rehabilitation to restore gamma function and improve motor recovery in stroke mice.

Constraint Induced Movement Therapy Confers only a Transient Behavioral Benefit but Enduring Functional Circuit-Level Changes after Experimental TBI.

This study shows that CIMT provides temporary behavioral benefits but lasting changes in brain circuits after TBI in rats.

Harnessing early multimodal motor training to drive motor recovery and brain-wide structural reorganization after stroke

This study shows that early multimodal motor training after stroke improves motor function and causes widespread brain structural changes in rats.

Self-organizing recruitment of compensatory areas maximizes residual motor performance post-stroke

This study develops a neuro-musculoskeletal model to show how compensatory motor areas are recruited post-stroke to maximize residual motor performance through homeostatic and reinforcement learning processes.

EEG Responses to Upper Limb Pinprick Stimulation in Acute and Early Subacute Motor and Sensorimotor Stroke

This study uses EEG during pinprick stimulation to assess sensorimotor impairments in stroke patients, finding correlations between EEG oscillations and recovery outcomes.

Theoretical proposal for restoration of hand motor function utilizing plasticity of motor-cortical interhemispheric interaction

This paper proposes a rehabilitation strategy for hand motor recovery after stroke by leveraging interhemispheric plasticity through bilateral proprioceptive-motor coupling and movement training.

Refined movement analysis in the Staircase test reveals differential motor deficits in mouse models of stroke

The paper uses machine learning to analyze movement in mouse stroke models, revealing distinct motor deficits based on lesion location.

Corticospinal and corticoreticulospinal projections benefit motor behaviors in chronic stroke

This study examines how corticospinal and corticoreticulospinal pathways relate to motor behaviors in chronic stroke patients, finding distinct contributions to motor control, strength, and muscle individuation in proximal and distal upper extremity segments.

Multi-site identification and generalization of clusters of walking impairment in individuals with chronic stroke and neurotypical controls

The paper identifies and generalizes walking impairment clusters in stroke survivors and controls using spatiotemporal and force data across multiple sites.

Loss of finger control complexity and intrusion of flexor biases are dissociable in finger individuation impairment after stroke

This study examines finger individuation impairment after stroke, finding two dissociable factors: loss of control complexity and flexor bias intrusion.

Intermuscular coherences of plantarflexors during walking suggest distinct neural origin and function for alpha and beta/low-gamma bands after stroke

This study examines intermuscular coherences in plantarflexor muscles post-stroke, finding degraded beta and low-gamma coherence on the paretic side and preserved alpha coherence linked to propulsive impulse.

Data-driven biomarkers outperform theory-based biomarkers in predicting stroke motor outcomes

This study compares data-driven and theory-based biomarkers for predicting chronic motor outcomes after stroke, finding data-driven models perform better, especially when using structural disconnection measures.

Post-Ischemic Reorganization of Sensory Responses in Cerebral Cortex

This study investigates post-ischemic connectivity between premotor and sensory cortex in rats following a primary motor cortex injury, finding evidence of crosstalk and functional recovery.

Speed-dependent biomechanical changes vary across individual gait metrics post-stroke relative to neurotypical adults

This study examines how fast walking affects gait kinematics in stroke survivors compared to neurotypical adults, finding varied biomechanical responses across metrics.

Improved cognitive-motor processing speed and decreased functional connectivity after high intensity aerobic exercise in individuals with chronic stroke

This study examines if high intensity aerobic exercise with motor training improves cognitive-motor function and functional connectivity in chronic stroke patients, finding improved processing speed and reduced connectivity.

Upper limb rehabilitation after stroke: constraint versus intensive training. A longitudinal case-control study correlating motor performance with fMRI data

This study compares brain reorganization in stroke patients undergoing constraint-induced movement therapy components, finding distinct patterns linked to constraint and intensive training.

The kinematics of 3D arm movements in sub-acute stroke: impaired inter-joint coordination caused by both weakness and flexor synergy intrusion

This study examines how weakness and flexor synergy intrusion affect arm movement coordination in sub-acute stroke patients using kinematic analysis and clinical scales.

Separating the control of moving and holding in post-stroke arm paresis

This study investigates whether control of moving and holding is independently affected in stroke patients, finding functional separation between these modes of control despite shared characteristics in resting biases and movement synergies.

The proportional recovery rule redux: Arguments for its biological and predictive relevance

The paper evaluates the proportional recovery rule (PRR) as a model for motor impairment recovery post-stroke, finding support for its biological relevance and introducing statistical methods to assess recovery models.

Deep learning based behavioral profiling of rodent stroke recovery

This paper develops a deep learning-based method for analyzing rodent stroke recovery using 3D gait tracking and benchmarking against conventional tests.