Topic · Reproductive Medicine · Medicine

Ovarian cancer diagnosis and treatment

OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.

5 papers

Conserved cell state dynamics reveal targetable resistance patterns in ovarian high-grade serous carcinoma

Anna Pirttikoski, Shabnaz Koochakkhani, Laura Gall-Mas, Wojciech Senkowski, David Fontaneda-Arenas, Jun Dai, Matías Marín Falco, Erdoğan Pekcan Erkan, Johanna Hynninen, Krister Wennerberg, Anna Vähärautio

The paper identifies conserved cell states in ovarian high-grade serous carcinoma that correlate with poor prognosis and presents actionable targets for improving platinum response.

Cell Death Discovery · Oct 30, 2026Peer-reviewedCancer Biology

A Collagen-Based 3D Microtissue Platform Preserves Structural, Molecular, and Therapeutic Heterogeneity in Ovarian Cancer

Parnaz Soori, Mohammadreza Javan, Lacey Winstone, Breanne Bernice Bevelander, Raquel Santamaria Cuevas, Michael Dean Chamberlain

This paper develops a collagen-based 3D microtissue model of ovarian cancer that preserves structural, molecular, and therapeutic heterogeneity across different histotypes.

bioRxiv · Oct 28, 2026 · PreprintCancer Biology

Tumour architecture shapes polarized epithelial states that predict survival in high-grade serous ovarian cancer

Sarah Nersesian, John Abou‐Hamad, Emma Durocher, Gaëlle Akiki, Céline Domecq, Athena Southworth, Katrina N. Verey, Hugh H. Deng, Yudith Ramos-Valdes, Liliane Meunier, Manon de Ladurantaye, Trevor G. Shepherd, Anne-Marie Mes Masson, Anne-Marie Mes-Masson, Basile Tessier Cloutier, David P. Cook

The paper identifies a polarization axis in ovarian cancer cells linked to tumor architecture and survival, showing SecB cells correlate with poor prognosis and metastasis.

bioRxiv · Oct 22, 2026 · PreprintCancer Biology

Spatial transcriptomics reveals interferon pathway enrichment in early relapsing serous carcinoma

Franziska Niemeyer, Niina Aho, Satu M. Hänninen, Omar Youssef, Olli Carpén, Andrew M. Erickson, Anna Ray Laury

This study uses spatial transcriptomics to identify interferon pathway enrichment in early relapsing high-grade serous carcinoma, linking it to poor prognosis and suggesting C3 as a biomarker.

bioRxiv · Oct 13, 2026 · PreprintCancer Biology

Targeting MAT2A-S-adenosylmethionine (SAM) Axis Attenuates DNA Damage Response and Cancer Stemness to Increase Platinum Sensitivity in Ovarian Cancer

Shu Zhang, Zhen Fu, Yanchi Zhou, Tara X. Metcalfe, Truc T. Vuong, Lindsay W Brubaker, Benjamin Guy Bitler, Heather M. O’Hagan, Kenneth P. Nephew

Blocking MAT2A-driven SAM synthesis in ovarian cancer cells prevents cisplatin-induced DNA hypermethylation, impairs DNA repair signaling, and blocks stem cell enrichment, sensitizing MTAP-proficient and MTAP-deficient lines.

bioRxiv · Oct 13, 2026 · PreprintCancer Biology✦ In-depth digest