Menopause: Health Impacts and Treatments

The Cardiovascular Benefit of Menopause Hormone Treatment is Age-Dependent in Ldlr-/- Mice

This study shows that menopause hormone treatment (E2) reduces atherosclerosis in young mice but not older mice, due to age-related changes in inflammation and estrogen receptor signaling.

Efficacy of postmenopausal estrogen replacement in SIV-infected female macaques on antiretroviral therapy.

This study evaluates the effects of estrogen replacement in SIV-infected female macaques on ART, finding no significant impact on viral dynamics but benefits for bone health.

Novel estrogen replacement combination therapy including the investigational drug davunetide

This study tests NAP as a non-hormonal alternative to estrogen replacement therapy in ovariectomized mice, showing improved grip strength but no significant cognitive or imaging differences.

Brain anatomy in major hormonal transition phases: Longitudinal and cross-sectional volume associations with menarche and menopause

The paper examines brain volume changes associated with menarche and menopause using MRI data, finding overlapping but opposing effects in specific brain regions across both phases.

Associations of endogenous and exogenous hormonal exposures and cardiovascular disease in women - A FinnGen study

This paper investigates associations between genetic and exogenous estrogen exposure and cardiovascular disease risk in women using GWAS and register-based hormone data.

Reproductive history differentially shapes the neural response of middle-aged females to estradiol therapy after a metabolic challenge

This study shows that reproductive history and APOE genotype influence how middle-aged females respond to estradiol therapy and metabolic stress, with primiparous hAPOE4 females showing increased inflammation and memory impairment.

Effect of a Growth Factor-Rich Platelet Lysate Gel with or without Uncaria tomentosa Extract on a Rat Model of Postmenopausal Vaginal Atrophy

This study evaluates a platelet lysate gel with or without Uncaria tomentosa extract in a rat model of postmenopausal vaginal atrophy, finding that 20% PL alone effectively reverses atrophy without inflammation.

Gray matter volume in women with the BRCA mutation with and without ovarian removal

This study examines gray matter volume changes in BRCA mutation carriers before and after ovarian removal, finding reduced volume in some groups and potential benefits of hormone replacement therapy.

Brain Specific Estrogen Ameliorates Cognitive Effects of Surgical Menopause in Mice

This study shows that brain-specific estrogen delivery via DHED improves spatial and working memory in post-menopausal mice.

Menopause, Brain Anatomy, Cognition and Alzheimer's Disease

This study examines the relationship between menopause status, type, and age at menopause with cognition, Alzheimer's Disease, and brain anatomy using UK Biobank data, finding no direct brain impact but a positive correlation between non-surgical menopause age and cognition, and confirming increased AD risk with early or surgical menopause.

Genomic insights into the mechanism of NK3R antagonists for treatment of menopausal vasomotor symptoms

This paper identifies a genetic association between NK3R (TACR3) and menopausal vasomotor symptoms (VMS) using GWAS, while finding no link between rare NK3R variants and VMS despite the efficacy of NK3R antagonists.