Research on Leishmaniasis Studies

This study analyzes the genome diversity of Leishmania aethiopica, identifying interspecific hybrids and revealing genetic diversity and recombination patterns.

LeishMANIAdb compiles experimental and predicted Leishmania secretomes and host-pathogen interactions to aid in understanding virulence mechanisms and identifying therapeutic targets.

This study uses multi-omics analysis to show that aneuploidy in Leishmania causes proportional changes in transcript and protein abundance, with post-transcriptional regulation compensating for some effects.

This paper develops CRISPR-based assays for detecting Leishmania species, showing high sensitivity and specificity for genus and subgenus level identification.

This paper shows Spergulin-A, a plant compound, kills Leishmania donovani inside macrophages by activating the P2X7R-P38MAPK signaling pathway.

This study functionally characterizes PRMTs in Leishmania braziliensis, showing PRMT1 and PRMT5 are required for macrophage infection and axenic amastigote proliferation.

The paper quantifies transcriptome and metabolome changes in Leishmania during quiescence induced by drug pressure or stationary phase, revealing global transcriptional reduction and specific upregulation of membrane and autophagy-related genes.

The paper analyzes genomic variation in Leishmania tropica isolates to reveal mechanisms of genetic exchange and genome plasticity associated with treatment failure and relapse.

The paper shows genome instability in Leishmania enables fitness gain through epistatic gene copy number variations and compensatory post-transcriptional mechanisms.

The paper uses high throughput single-cell genome sequencing to study mosaic aneuploidy in Leishmania donovani, finding rapid karyotype changes and chromosome-specific adaptations.

This study develops a probabilistic model to simulate Leishmania transmission dynamics, showing that skin heterogeneity affects short-lived flies while vector population dynamics dominate for longer-lived flies.

The paper detects Leishmania and Trypanosoma species in sandflies from Kenya, implicating Sergentomyia squamipleuris in leishmaniasis transmission and suggesting zoonotic potential.

The paper tests CRISPR-Cas9 and glmS ribozyme systems for gene disruption and knock-down in Leishmania tarentolae, finding success with CRISPR-Cas9 and limited effectiveness with glmS.

This study examines the evolutionary history and hybridization of Leishmania parasites using whole genome sequencing, revealing ecological divergence and genetic mosaic ancestry in hybrids.

The paper shows Leishmania donovani lacks detectable DNA methylation, enabling enrichment of parasite DNA from mixed samples using methyl-binding columns.

The paper analyzes genetic variability and immune response potential of salivary proteins in Phlebotomus papatasi sand flies from Egypt and Jordan.

The paper identifies a conserved RNA stem-loop in the LdNT3 mRNA 3' UTR that mediates purine-responsive upregulation in Leishmania donovani, with species-specific functionality due to variant bases.

The paper analyzes whole-genome sequences of Leishmania donovani isolates from Ethiopia to investigate hybridization patterns and recombination in natural populations.

The paper presents a comprehensive genome-wide study of Leishmania donovani complex isolates, revealing genetic diversity and structural variation across species and geographical regions.

This study uses SILAC-based proteomics to identify 86 differentially expressed proteins in murine macrophages infected with Leishmania donovani, revealing changes in host metabolism and lysosomal organization.

The paper uses meta-taxonomic analysis of gut flora in VL cases and controls to identify microbial associations with disease status and diversity.

This paper identifies transcriptional signatures in whole blood associated with asymptomatic Leishmania donovani infection, active visceral leishmaniasis, and treatment outcomes with different amphotericin B regimens.

This study identifies 1,400 mRNA binding proteins in Leishmania mexicana across three lifecycle stages, revealing stage-specific RNA binding and limited correlation between mRNA levels and protein expression.

This paper assembles and annotates reference genomes for Leishmania naiffi and Leishmania guyanensis, revealing genomic traits and evolutionary patterns in the Viannia subgenus.