Topic · Epidemiology · Medicine
OpenAlex topic; a paper is listed when OpenAlex scores it at least 0.5 for this topic.
277 papers
Dianbo Liu, Luca Albergante, T. J. Newman, David Horn
The paper explains a VSG hierarchy in Trypanosoma brucei infections through a growth-rate mechanism linked to VSG length, showing shorter VSGs trigger immune responses while longer VSGs persist due to slower growth.
Scientific Reports · Jul 13, 2018Peer-reviewedSystems Biology
Yijian Qiu, Vijay Shankar, Rooksana E. Noorai, Nelson Yeung, Sarah Grace McAlpine, James C. Morris
The paper identifies a post-transcriptional regulatory element in the 3UTR of a lifecycle stage-regulated gene in Trypanosoma brucei that mediates glucose-responsive translational control.
bioRxiv · May 24, 2018 · PreprintGenetics
Luisa Berná, Matías Rodriguez, María Laura Chiribao, Adriana Parodi‐Talice, Sebastián Pita, Gastón Rijo, Fernando Álvarez-Valín, Carlos Robello
The paper uses long-read sequencing to improve genome assembly and annotation of Trypanosoma cruzi, revealing new repetitive sequences and gene structures.
Microbial Genomics · Apr 30, 2018Peer-reviewedGenomics
Magambo Phillip Kimuda, Harry A. Noyes, Julius Mulindwa, John Enyaru, Vincent Pius Alibu, Issa Sidibé, Dieuodonne Mumba, Christiane Hertz‐Fowler, Annette MacLeod, Özlem Taştan Bishop, Enock Matovu
The paper investigates associations between APOL1 variants and HAT risk in Ugandan populations, finding no significant associations after correction for multiple testing.
PLoS neglected tropical diseases · Feb 22, 2018Peer-reviewedGenetics
Bernardin Ahouty, Mathurin Koffi, Hamidou Ilboudo, Gustave Simo, Enock Matovu, Julius Mulindwa, Christiane Hertz‐Fowler, Bruno Bucheton, Issa Sidibé, Vincent Jamonneau, Annette MacLeod, Harry A. Noyes, Assanvo Simon-Pierre N’Guetta
This paper investigates genetic associations with susceptibility to Human African Trypanosomiasis in Côte d’Ivoire using a candidate gene approach and finds suggestive but non-significant associations in several immune-related genes.
PLoS neglected tropical diseases · Oct 23, 2017Peer-reviewedGenetics
Laura E. Kirby, Donna J. Koslowsky
The paper shows that Trypanosoma brucei mitochondrial genes are dual-coding, using RNA editing to access different reading frames and protect genetic information from drift in non-selective conditions.
PLoS neglected tropical diseases · Oct 9, 2017Peer-reviewedGenetics
Paul Capewell, Bruno Bucheton, Caroline Clucas, Hamidou Ilboudo, Anneli Cooper, Taylor-Anne Gorman, Kerry O’Neill, Agapitos Patakas, Andrew M. Platt, Heli Vaikkinen, William Weir, Mamadou Camara, Paul Garside, Vincent Jamonneau, Annette MacLeod
The paper identifies genetic factors and immune mechanisms associated with symptom severity in human African trypanosomiasis using transcriptome analysis and an animal model.
bioRxiv · Sep 5, 2017 · PreprintGenetics