Trypanosoma species research and implications

This study identifies the molecular architecture of the TAC60-p166 contact site in Trypanosoma brucei, showing hydrophobic interactions drive its formation rather than electrostatic forces.

This paper updates the genome assembly and annotation of Lotmaria passim, revealing chromosomal duplications and aneuploidy, and provides a reference for studying its adaptation to the honey bee gut and potential treatments for pollinator infections.

This study compares PCR and microscopy for detecting trypanosome infections in tsetse flies and finds PCR is 1.9-9.3 times more sensitive, identifies species, and reveals cattle and human bloodmeals dominate.

This study investigates how branched-chain amino acids (BCAAs) affect the proteomic profile of Pro-induced differentiation in Trypanosoma cruzi, revealing metabolic changes linked to reduced infectivity.

This paper shows FAP20 is essential for flagellum assembly in Trypanosoma brucei, causing lethal defects, unlike its role in other organisms.

This study evaluates the impact of a national tsetse control program using Tiny Targets in Uganda, showing reduced tsetse abundance and low population levels across 4000 km2.

This study shows that ST8Sia2 polysialyltransferase reduces Trypanosoma cruzi infection by modulating host polysialylation.

This study identifies a camelid single-domain antibody that allosterically inhibits trypanosomatid pyruvate kinases, reducing parasite growth.

The paper identifies KREH2 helicase as a repressor of ND7 mRNA editing in T. brucei by modulating canonical and moonlighting gRNA utilization, revealing its dual role in developmental editing control.

This study shows that TbPam16 and TbPam18 in Trypanosoma brucei regulate maxicircle replication in mitochondria through a novel regulatory circuit involving MaRF11 and proteasomal control.

This study reviews and analyzes preclinical treatments for Chagas disease using animal models, finding promising candidates but limited clinical success.

The paper identifies Triatoma breyeri in Bolivia and suggests it was recently introduced through human activity, remaining confined to a specific dry valley region.

The paper develops a fluorescence polarization-based assay to identify bromodomain inhibitors of TcBDF2, finding 7 novel compounds that bind TcBDF2 with dissociation constants between 1 and 3 M.

This paper creates double null mutants of TbGT8 and TbGT10 in Trypanosoma brucei, showing reduced pNAL synthesis but normal TfR function and parasite viability.

This study improves serodiagnosis of T. vivax in cattle using recombinant antigens, finding higher infection rates in Argentina.

This study establishes a hamster model of Trypanosoma cruzi infection using bioluminescence imaging, revealing chronic tissue pathology and motor dysfunction not seen in mice.

This study shows venturicidin A targets ATP synthase in Trypanosoma brucei, causing mitochondrial membrane potential loss and kDNA loss, suggesting it as a potential antitrypanosomatid drug.

The paper describes a panel of bioluminescent and fluorescent Trypanosoma cruzi strains to study Chagas disease, enabling real-time monitoring of infection dynamics and drug screening.

This study investigates the role of the actomyosin system in maintaining endosomal integrity in Trypanosoma brucei using imaging and biochemical assays.

This study shows that CD39 expression on regulatory T cells suppresses CD8+ T cell responses during Trypanosoma cruzi infection, highlighting its role in immune regulation.

This study investigates the role of intrinsic disorder in invariant surface glycoproteins (ISGs) of African trypanosomes, showing they can switch between compact and elongated conformers to balance immune evasion and host interaction.

This paper demonstrates a marker-free gene editing method using SpCas9 ribonucleoprotein complexes in trypanosomatids, enabling efficient genetic modifications in various life stages of T. brucei, T. congolense, and Leishmania promastigotes.

This paper identifies TcREG9.1 as a regulator of attachment and morphological development in Trypanosoma congolense, showing its role in surface adhesion and transmission.

This paper genetically modifies Crithidia bombi to enable visualization and protein localization, providing tools to study host-pathogen interactions.

This study demonstrates that Tbg2 trypanosomes can establish in tsetse flies and infect mice, showing their ability to transition from procyclic to bloodstream form in vivo.

This study compares gene expression profiles between early and late stage r-HAT patients in Malawi, identifying differentially expressed genes and potential diagnostic biomarkers.

This study identifies natural nucleosides as activators of PKA in trypanosomatid pathogens, showing they replace cAMP in allosteric regulation through specific binding to CNB domains.

This study compares the vascular interactions of three Trypanosoma species, showing T. vivax sequesters in endothelium and has unique receptor expression changes.

This study identifies RBP42 as a regulator of central carbon and energy metabolism in Trypanosoma brucei by analyzing its RNA-binding interactions and metabolic effects.