Olfactory and Sensory Function Studies

Respiratory Phase Orchestrates Human Olfactory Cortical Dynamics

This paper shows that odor processing in the human brain is structured by breathing phase, not time, and introduces RPL-ERSPs as a method to decode odors using EEG and respiration data.

Connexin 36-mediated gap junctions contribute to fine odor discrimination and excitation of mitral cells in the mouse olfactory bulb

This study shows that Cx36 gap junctions in the mouse olfactory bulb are important for fine odor discrimination and late excitation of mitral cells.

The superficial tufted and mitral cell output neurons of the mouse olfactory bulb have dual roles in insulin sensing

The paper studies insulin sensitivity in superficial tufted cells (sTCs) of the mouse olfactory bulb, finding they respond to insulin with increased firing frequency.

Genome-Wide Association Study Meta-Analysis Uncovers Novel Genetic Variants Associated with Olfactory Dysfunction

This paper identifies a novel genetic locus associated with olfactory dysfunction through a genome-wide association study meta-analysis and shows causal links to various health outcomes.

Tastes and retronasal odours evoke a shared flavour-specific neural code in the human insula

The paper shows retronasal odours and their paired tastants evoke similar insular neural patterns, highlighting shared flavour processing.

A low-cost and open-source olfactometer to precisely deliver single odours and odour mixtures

This paper describes a low-cost, open-source olfactometer for precise odour delivery in behavioural studies.

Early postpartum development of pup urine preference in mothers

The paper shows that postpartum mothers develop a preference for pup urine, which involves both hormonal changes and chemosensory cues, and identifies specific volatile compounds in pup urine that may drive this behavior.

Development of the Olfactory and Vomeronasal Systems in the Fossorial Water Vole (Arvicola scherman). I. The Late Prenatal Stages

This paper examines the prenatal development of the olfactory and vomeronasal systems in the fossorial water vole, revealing accelerated maturation compared to laboratory rodents.

Mice navigate scent trails using predictive policies

This study shows mice use predictive policies to navigate scent trails by integrating bilateral olfactory input and short-term memory.

Mice and humans evaluate odor stimulus strength using common psychophysical principles

This study shows mice and humans use a common perceptual scale to assess odor intensity, demonstrating shared principles in stimulus evaluation.

A quantitative framework for predicting odor intensity across molecule and mixtures

This study develops a deep learning framework to predict odor intensity from physical properties of molecules and mixtures, overcoming limitations of traditional methods.

The olfactory bulb reflects structural plasticity within a genetically stable olfactory network

The paper investigates the heritability of olfactory bulb volume and olfactory network architecture using twin data and machine learning, finding that genetic factors influence the network as a whole.

Genome-wide and gene expression analyses of the hagfish olfactory receptors illuminate lineage-specific diversification of olfaction in basal vertebrates

This study identifies and characterizes olfactory receptor repertoires in hagfish, revealing that V2Rs originated in the vertebrate common ancestor and diversified in hagfish for adaptation to deep-sea environments.

Biophysically relevant network model of the piriform cortex predicts odor frequency encoding using network mechanisms

The paper develops a biophysically relevant piriform cortex network model to show that odor frequency discrimination occurs through distributed mechanisms and specific circuit motifs.

Coding odor modality in piriform cortex efficiently with low-dimensional subspaces: a Shared Covariance Decoding approach

The paper shows that modality information is efficiently encoded in piriform cortex using a novel decoding method called Shared Covariance Decoding.

The Vomeronasal System of Talpa occidentalis: A Combined Histological, Immunohistochemical, and Lectin-Binding Approach

This paper characterizes the vomeronasal system of the Iberian mole, revealing unique anatomical and molecular features compared to other mammals.

Neurochemical Features and Glycan Patterns in the Wapiti Vomeronasal Pathway

This study characterizes the vomeronasal system in wapiti, revealing its anatomical and neurochemical features through histological and immunohistochemical analyses.

Brain-wide connectivity and novelty response of the dorsal endopiriform nucleus in mice

This study maps the connectivity and function of the dorsal endopiriform nucleus in mice, revealing its role in olfaction and response to novel stimuli through Oxtr-expressing neurons.

Smelling the Risk: Early Olfactory Deficits, Brain Networks, and Blood Markers of Alzheimers Disease Risk in Humanized APOE Mice

This study identifies olfactory deficits as early biomarkers of Alzheimer's disease risk by linking behavior, brain networks, and blood transcriptomics in humanized APOE mice.

Developmental olfactory dysfunction and abnormal odor memory in immune-challenged Disc1+/- mice

The paper investigates how immune challenges in Disc1+/- mice affect olfactory bulb activity and lead to memory impairments in the hippocampal-prefrontal network.

Olfactory bulb and cortex activity reflects subjective odor intensity perception rather than concentration

The paper shows that the olfactory bulb and cortex use oscillatory dynamics to reflect perceived odor intensity rather than physical concentration.

Decoding Olfactory Bulb Output: A Behavioral Assessment of Rate, Synchrony, and Respiratory Phase Coding

This study investigates how mice encode odor information through spike rate, synchrony, and respiratory phase in the olfactory bulb using optogenetics and behavioral assays.

The anterior olfactory nucleus mediates curious exploration evoked by novel odors

This study investigates how the anterior olfactory nucleus (AON) and anterior piriform cortex (aPCx) contribute to novelty-evoked exploration in mice, finding that AON mediates immediate reactions to novel odors while aPCx supports stable odor memory.

Western diet reversibly alters the olfactory mucosa and impairs the response to appetitive food cues

This study shows that a Western diet alters olfactory epithelium physiology in mice, impairing odor response, but these effects are reversible upon diet withdrawal.

Mice discriminate odour source distance via sub-sniff temporal features of odour plumes

This study shows mice can distinguish odour sources at different distances by analyzing rapid temporal features of odour plumes, with neural responses correlating more strongly with high-frequency plume features than mean concentration.

The Functional and Genetic Architecture of Olfaction in Deer Mice

This study analyzes the olfactory genome of deer mice to reveal conserved and divergent components of the rodent olfactory subgenome and their evolutionary implications.

Olfactory dysfunction in a novel model of prodromal Parkinson's disease in adult zebrafish

This study develops a zebrafish model of prodromal Parkinson's disease that replicates olfactory impairment without motor deficits, showing recovery through neuroplasticity.

Age-Dependent, Odorant-Specific Changes in Olfactory Sensitivity in an Alzheimer's Disease Mouse Model

This study shows that Alzheimer's disease mice exhibit age-dependent, odorant-specific changes in olfactory sensitivity, with hyperosmia to esters at 2 months and hyposmia at 4 months.

Vitamin D regulates olfactory function via dual transcriptional and mTOR-dependent translational control of synaptic proteins

This study shows vitamin D regulates olfactory function through both transcriptional and mTOR-dependent translational control of synaptic proteins in mice.

Molecular and Spatial Organization of the Primary Olfactory System and its Responses to Social Odors

The paper maps molecular and spatial organization of the mouse primary olfactory system in response to social odors using MERFISH and identifies spatial domains of sensory responses.