Renal Diseases and Glomerulopathies

Novel regulators of zebrafish glomerular development

The paper identifies eight new genes involved in zebrafish glomerular development through transcriptome analysis and CRISPR-Cas9 screening, linking them to proteinuria and glomerular leakage.

Inhibition of p65 NF-κB enhances production of galactose-deficient IgA1 through suppression of C1GALT1 and SP1 in plasmablast-like cell subpopulations

The paper shows that inhibiting NF-κB/p65 increases galactose-deficient IgA1 production by reducing C1GALT1 expression and altering B cell subpopulations in IgAN patients.

Mucosal Inflammation as a Driver of Gd-IgA1 Production in IgA Nephropathy: Mechanistic Support for Targeted Therapies

This study shows mucosal cytokines drive Gd-IgA1 production in IgAN by expanding specific B cell populations, supporting therapies targeting mucosal immunity.

An endoplasmic reticulum resident molecular chaperone, GRP170, prevents stress-induced glomerular injury

This study shows that GRP170 protects podocytes from stress-induced glomerular injury by modulating the UPR, as demonstrated in a podocyte-specific knockout mouse model.

Disease-associated amino acid substitutions outside canonical motor motifs impair Myo1e localization and activity

This study shows that two MYO1E mutations, A92E and G562R, impair Myo1e localization and function, contributing to steroid-resistant nephrotic syndrome.

A Human Precision Cut Kidney Slice Platform for Studying Glomerular Biology and Therapeutic Responses

This study uses human precision cut kidney slices to analyze gene expression responses to culture conditions and IFNγ stimulation, showing reproducible APOL1 expression changes.

Molecular anatomy of the glomerular filtration barrier reveals topology-encoded albumin sieving

The paper uses cryo-ET and transport modeling to show that the glomerular basement membrane's void-network topology restricts albumin passage, explaining selectivity in the filtration barrier.