Testicular diseases and treatments

XPO1 Inhibition by Selinexor Induces Nuclear p53 and p21 Accumulation, Cell-Cycle Arrest and Apoptosis in Testicular Germ Cell Tumors

This study shows selinexor, an XPO1 inhibitor, reduces viability and induces cell-cycle arrest and apoptosis in testicular germ cell tumors by increasing nuclear p53 and p21.

“Mapping of Gonadal Development in Cryptorchidism: UTF-1 and Germ Cell Dysgenesis”

This study examines how cryptorchidism affects germ cell development and UTF-1 expression in testicular biopsies, finding reduced germ cell counts and UTF-1 expression in cryptorchid testes.

A Thiopurine-like Mutagenic Process Defines TGCT Subtypes

This study identifies a unique mutational signature, SBS87, in testicular germ cell tumors (TGCTs) that resembles thiopurine-induced DNA damage and is associated with tumor latency and telomere elongation.